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Molecules, Volume 22, Issue 9

September 2017 - 186 articles

Cover Story: Treating complex diseases, such as cancer, relies on interfering with a network of different target proteins. Within the family of matrix metalloproteinases (MMPs), several targets and anti-targets have been identified over decades of research. The time is ripe for developing small molecule inhibitors acting on several target proteins simultaneously, while leaving the anti-targets alone. A selective MMP-7/-13 small molecule inhibitor with precisely such an inhibition profile has now been developed. View Paper here
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Articles (186)

  • Feature Paper
  • Article
  • Open Access
15 Citations
5,365 Views
17 Pages

Studying the Structural Significance of Galectin Design by Playing a Modular Puzzle: Homodimer Generation from Human Tandem-Repeat-Type (Heterodimeric) Galectin-8 by Domain Shuffling

  • Anna-Kristin Ludwig,
  • Malwina Michalak,
  • Nadya Shilova,
  • Sabine André,
  • Herbert Kaltner,
  • Nicolai V. Bovin,
  • Jürgen Kopitz and
  • Hans-Joachim Gabius

19 September 2017

Tissue lectins are emerging (patho)physiological effectors with broad significance. The capacity of adhesion/growth-regulatory galectins to form functional complexes with distinct cellular glycoconjugates is based on molecular selection of matching p...

  • Article
  • Open Access
45 Citations
13,263 Views
18 Pages

Improving the Efficiency of New Automatic Dishwashing Detergent Formulation by Addition of Thermostable Lipase, Protease and Amylase

  • Ashwini Naganthran,
  • Malihe Masomian,
  • Raja Noor Zaliha Raja Abd. Rahman,
  • Mohd Shukuri Mohamad Ali and
  • Hisham Mohd Nooh

19 September 2017

The use of T1 lipase in automatic dishwashing detergent (ADD) is well established, but efficiency in hard water is very low. A new enzymatic environmentally-friendly dishwashing was formulated to be efficient in both soft and hard water. Thermostable...

  • Article
  • Open Access
28 Citations
9,739 Views
21 Pages

Chemoinformatic Database Building and in Silico Hit-Identification of Potential Multi-Targeting Bioactive Compounds Extracted from Mushroom Species

  • Annalisa Maruca,
  • Federica Moraca,
  • Roberta Rocca,
  • Fulvia Molisani,
  • Francesca Alcaro,
  • Maria Concetta Gidaro,
  • Stefano Alcaro,
  • Giosuè Costa and
  • Francesco Ortuso

19 September 2017

Mushrooms are widely-consumed fungi which contain natural compounds that can be used both for their nutritive and medicinal properties, i.e., taking advantage of their antimicrobial, antiviral, antitumor, anti-allergic, immunomodulation, anti-inflamm...

  • Article
  • Open Access
33 Citations
7,214 Views
18 Pages

The Native Fruit Geoffroea decorticans from Arid Northern Chile: Phenolic Composition, Antioxidant Activities and In Vitro Inhibition of Pro-Inflammatory and Metabolic Syndrome-Associated Enzymes

  • Felipe Jiménez-Aspee,
  • Cristina Theoduloz,
  • Maria Del Pilar C. Soriano,
  • Maider Ugalde-Arbizu,
  • Maria Rosa Alberto,
  • Iris Catiana Zampini,
  • Maria Inés Isla,
  • Mario J. Simirgiotis and
  • Guillermo Schmeda-Hirschmann

18 September 2017

The native tree Geoffroea decorticans (chañar) grows in the arid lands of northern Chile. It has been used as a food plant since prehistoric times. Phenolic-enriched extracts (PEEs) of Chilean chañar fruits were assessed for their chemical compositio...

  • Article
  • Open Access
13 Citations
6,124 Views
9 Pages

18 September 2017

Fermentation of Alnus sibirica (AS) stems using Lactobacillus plantarum subsp. argentoratensis was conducted and three compounds isolated from the Alnus species were identified for the first time, 7-(3,4-dihydroxyphenyl)-1-(4-hydroxyphenyl)-heptan-3-...

  • Feature Paper
  • Article
  • Open Access
6 Citations
6,659 Views
20 Pages

18 September 2017

A synthetic method that taps into the facile Lewis base (LB)→Lewis acid (LA) adduct forming reaction between the semiconducting polymeric LB and all carbon LA C60 for the construction of covalently linked donor-acceptor dyads and brush polymer of dya...

  • Article
  • Open Access
12 Citations
5,536 Views
17 Pages

18 September 2017

Ophiocordyceps sinensis is one rare medicinal fungus produced in the Qinghai-Tibetan Plateau. Its quality and price varies hugely with different habitat, and its numerous substitutes have sprung up in functional food markets. This paper aims to discr...

  • Article
  • Open Access
8 Citations
5,255 Views
8 Pages

Nematicidal Activity of 3-Acyltetramic Acid Analogues Against Pine Wood Nematode, Bursaphelenchus xylophilus

  • Hyo-Rim Lee,
  • Sung-Chan Lee,
  • Ji-Eun Lee,
  • Seon-Mi Seo,
  • Yong-Chul Jeong,
  • Chan-Sik Jung,
  • Mark G. Moloney and
  • Il-Kwon Park

18 September 2017

Among 98 3-acyltetramic acid analogues, compounds 1c, 2c, 2f and 2g, showed >90% nematicidal activity against the pine wood nematode Bursaphelenchus xylophilus at a 10 μg/mL concentration. The nematicidal activities of compounds 1d, 1h, and 2k wer...

  • Review
  • Open Access
31 Citations
9,154 Views
18 Pages

Cardiovascular Activity of the Chemical Constituents of Essential Oils

  • Tadeu Uggere De Andrade,
  • Girlandia Alexandre Brasil,
  • Denise Coutinho Endringer,
  • Flávio Rogério Da Nóbrega and
  • Damião Pergentino De Sousa

17 September 2017

Cardiovascular diseases are a leading cause of death in developed and developing countries and decrease the quality of life, which has enormous social and economic consequences for the population. Recent studies on essential oils have attracted atten...

  • Article
  • Open Access
25 Citations
7,195 Views
10 Pages

The Influence of Accelerated UV-A and Q-SUN Irradiation on the Antimicrobial Properties of Coatings Containing ZnO Nanoparticles

  • Małgorzata Mizielińska,
  • Łukasz Łopusiewicz,
  • Monika Mężyńska and
  • Artur Bartkowiak

17 September 2017

The influence of accelerated UV-A and Q-SUN irradiation on the antimicrobial properties of coatings containing ZnO nanoparticles was investigated using a polyethylene (PE) film covering. The results of the study showed that Methyl Hydroxypropyl Cellu...

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Molecules - ISSN 1420-3049