Dramatic Influence of Ionic Liquid and Ultrasound Irradiation on the Electrophilic Sulfinylation of Aromatic Compounds by Sulfinic Esters

The sulfinylation reaction of aromatic and hetero-aromatic compounds with sulfinic esters as electrophiles has been investigated in different ionic liquids and by means of different Lewis acid salts in order to get moderate to good yields of asymmetrical sulfoxides. Mixtures of 1-butyl-3-methylimidazolium chloride and aluminum chloride were found to be the most efficient and recyclable reaction framework. Ultrasound sonication appeared to be the most useful and green activation method to afford the sulfoxides in yields better than or equivalent to those obtained under the longer-lasting conventional stirring conditions.

The importance of sulfoxides in organic syntheses has attracted the attention of chemists to find new methodologies for sulfoxide synthesis. Aliphatic and aromatic sulfoxides have been prepared by the direct and popular oxidation of thioethers [19,20], by indirect reduction of sulfones [21], or by nucleophillic interaction of Grignard reagents on sulfinic esters [22,23], and sulfoxides [24].
The ionic liquid ethylammonium nitrate was synthesized already in the early 1910s [34]. Subsequently, research and development of ionic liquid has concentrated mainly on electrochemical applications since 1948 [35]. In the early 1980s ionic liquids (ILs) attained much more attention owing to their unique chemical and physical properties of non-volatility, non-flammability, thermal stability, and controlled miscibility [35,36]. They have been also used as green solvents in various biphasic ILs-transition metal-catalyzed organic reactions in order to improve catalyst storage, handling, recycling and reuse. The first successful combination of an ionic liquid, dialkylimidazolium chloride, with aluminum chloride used as a Lewis acid catalyst in Friedel-Crafts acylations was reported in 1986 [37].
One of viewpoints on green chemistry, ultrasound irradiation has been regarded as a clean and useful protocol during the last three decades in comparison with traditional activation methods. Many categories of homogeneous or heterogeneous reactions accelerated by ultrasound irradiation have been launched in order to reduce the reaction time, and generate fewer byproducts and a higher yield of the main product [38,39].
In this present work, we integrate the advantages of ultrasound irradiation accelerated sulfinylation of arenes and hetero-arenes with stable alkyl alkanesulfinates/arenesulfinates in the presence of different acidic catalysts to produce asymmetrical sulfoxides (Scheme 1). Several Lewis acid salts as well as a task-specific ionic liquid and the mixtures of 1-butyl-3-methyl-imidazolium chloride and different Lewis acid salts with different Lewis acidity were investigated. to their unique chemical and physical properties of non-volatility, non-flammability, thermal stability, and controlled miscibility [35,36]. They have been also used as green solvents in various biphasic ILstransition metal-catalyzed organic reactions in order to improve catalyst storage, handling, recycling and reuse. The first successful combination of an ionic liquid, dialkylimidazolium chloride, with aluminum chloride used as a Lewis acid catalyst in Friedel-Crafts acylations was reported in 1986 [37]. One of viewpoints on green chemistry, ultrasound irradiation has been regarded as a clean and useful protocol during the last three decades in comparison with traditional activation methods. Many categories of homogeneous or heterogeneous reactions accelerated by ultrasound irradiation have been launched in order to reduce the reaction time, and generate fewer byproducts and a higher yield of the main product [38,39].
In this present work, we integrate the advantages of ultrasound irradiation accelerated sulfinylation of arenes and hetero-arenes with stable alkyl alkanesulfinates/arenesulfinates in the presence of different acidic catalysts to produce asymmetrical sulfoxides (Scheme 1). Several Lewis acid salts as well as a task-specific ionic liquid and the mixtures of 1-butyl-3-methyl-imidazolium chloride and different Lewis acid salts with different Lewis acidity were investigated.

Results
Based on the previous literature and the points of view on green chemistry, a series of Lewis acid salts, for instance bismuth(III) triflate, lanthanide(III) triflate, and copper(II) triflate were used as the acidic catalysts for the solvent-free sulfinylation of 1,3-dimethoxybenzene (our arbitrarily-chosen model substrate) by methyl benzenesulfinate under ultrasound irradiation in order to compare with aluminum chloride catalyst (Entries 1-4, Table 1). The results showed that aluminum chloride efficiently catalyzed the sulfinylation of 1,3-dimethoxybenzene into 2,4-dimethoxy-1-(phenylsulfinyl)benzene under solvent-free as well as solvent reaction condition (Entry 5, Table 1); however, the product selectivity of 2,4-dimethoxy-1-(phenylsulfinyl)benzene reported by GC/MS analyses was achieved 60% from the solvent-free sulfinylation lower than 88% from the solvent sulfinylation owing to severe demethylation of methoxy substituent on aromatic ring. In addition, it is not safe to add anhydrous aluminum chloride directly into the reaction mixture due to the large exotherm.
On the way to find out a green and recyclable acidic catalyst, a series of ionic liquids (Entries 6-12, Table 1), e.g., a task-specific ionic liquid, 1-methyl-3-(4-sulfobutyl)imidazolium hydrogen sulfate, [(HSO3) 4 C4C1Im]HSO4, an eutectic mixture of choline chloride and zinc chloride as well as the mixture of [Bmim]Cl and several Lewis acid salts were investigated. The results substantiate our choice of chloroaluminate-based 1-butyl-3-methylimidazole chloride as the most efficient catalyst under ultrasound irradiation. Owing to the mild and efficient catalysis of chloroaluminate-based 1-butyl-3-Scheme 1. Synthesis of sulfoxides from alkyl alkanesulfinate/arenesulfinate via the sulfinylation reaction.

Results
Based on the previous literature and the points of view on green chemistry, a series of Lewis acid salts, for instance bismuth(III) triflate, lanthanide(III) triflate, and copper(II) triflate were used as the acidic catalysts for the solvent-free sulfinylation of 1,3-dimethoxybenzene (our arbitrarily-chosen model substrate) by methyl benzenesulfinate under ultrasound irradiation in order to compare with aluminum chloride catalyst (Entries 1-4, Table 1). The results showed that aluminum chloride efficiently catalyzed the sulfinylation of 1,3-dimethoxybenzene into 2,4-dimethoxy-1-(phenylsulfinyl)benzene under solvent-free as well as solvent reaction condition (Entry 5, Table 1); however, the product selectivity of 2,4-dimethoxy-1-(phenylsulfinyl)benzene reported by GC/MS analyses was achieved 60% from the solvent-free sulfinylation lower than 88% from the solvent sulfinylation owing to severe demethylation of methoxy substituent on aromatic ring. In addition, it is not safe to add anhydrous aluminum chloride directly into the reaction mixture due to the large exotherm.
On the way to find out a green and recyclable acidic catalyst, a series of ionic liquids (Entries -6-12, Table 1), e.g., a task-specific ionic liquid, 1-methyl-3-(4-sulfobutyl)imidazolium hydrogen sulfate,  4 , an eutectic mixture of choline chloride and zinc chloride as well as the mixture of [Bmim]Cl and several Lewis acid salts were investigated. The results substantiate our choice of chloroaluminate-based 1-butyl-3-methylimidazole chloride as the most efficient catalyst under ultrasound irradiation. Owing to the mild and efficient catalysis of chloroaluminate-based 1-butyl-3-methylimidazole chloride, demethylation of methoxy substituted group was not found by GC/MS analyses and thin layer chromatography (TLC) during the reaction period.
The composition of chloroaluminate-based ionic liquids is expressed as the apparent AlCl 3 mole fraction (N) in order to vary their Lewis acidity. They are classified into three types such as base liquids, neutral liquids and acidic liquids [37,40]. Further experiments on the AlCl 3 mole fraction (Entries 12-14, (1-butyl-3-methylimmidazole combined with twice molar amount of aluminum chloride, N = 0.67) promoted the sulfinylation of 1,3-dimethoxybenzene to take place most efficiently. methylimidazole chloride, demethylation of methoxy substituted group was not found by GC/MS analyses and thin layer chromatography (TLC) during the reaction period. The composition of chloroaluminate-based ionic liquids is expressed as the apparent AlCl3 mole fraction (N) in order to vary their Lewis acidity. They are classified into three types such as base liquids, neutral liquids and acidic liquids [37,40]. Further experiments on the AlCl3 mole fraction (Entries 12-14, Table 1) demonstrated that [Bmim]Cl·2AlCl3 or [Bmim][Al2Cl7] (1-butyl-3-methylimmidazole combined with twice molar amount of aluminum chloride, N = 0.67) promoted the sulfinylation of 1,3-dimethoxybenzene to take place most efficiently. In order to improve the reaction conversion and yield of sulfoxide, the molar ratio of [Bmim]Cl·2AlCl3, 1,3-dimethoxybenzene, methyl benzenesulfinate was investigated (Entries 15-17, Table 1). Subsequently, the other reaction factors consisting of reaction temperatures (e.g., room temperature, 50 °C and 60 °C), the reaction time, and the activation methods (e.g., magnetic stirring, ultrasound irradiation and microwave irradiation) were also studied. Consequently, the most efficient procedure for the sulfinylation of 1,3-dimethoxybenzene (1 mmol) with methyl benzenesulfinate (1 mmol) in the appropriate amount of [Bmim]Cl·2AlCl3 (1.2 mmol) performed under ultrasound irradiation for one-hour at room temperature was selected (Entry 1, Table 2). Further experiments showed that the highest yield of 2,4-dimethoxy-1-(phenylsulfinyl)benzene was achieved up to 72% after one-hour ultrasound irradiation, while it was 69% after four-hour magnetic stirring. In addition, microwave irradiation is not an efficient method for this reaction owing to the decomposition of reaction mixture at warm temperature (approx. 50 °C).
The optimized conditions were used to investigate the substrate scope of the sulfinylation. Altogether ten aromatic and hetero-aromatic compounds were subjected to [Bmim] In order to improve the reaction conversion and yield of sulfoxide, the molar ratio of [Bmim]Cl·2AlCl 3 , 1,3-dimethoxybenzene, methyl benzenesulfinate was investigated (Entries 15-17, Table 1). Subsequently, the other reaction factors consisting of reaction temperatures (e.g., room temperature, 50 • C and 60 • C), the reaction time, and the activation methods (e.g., magnetic stirring, ultrasound irradiation and microwave irradiation) were also studied. Consequently, the most efficient procedure for the sulfinylation of 1,3-dimethoxybenzene (1 mmol) with methyl benzenesulfinate (1 mmol) in the appropriate amount of [Bmim]Cl·2AlCl 3 (1.2 mmol) performed under ultrasound irradiation for one-hour at room temperature was selected (Entry 1, Table 2). Further experiments showed that the highest yield of 2,4-dimethoxy-1-(phenylsulfinyl)benzene was achieved up to 72% after one-hour ultrasound irradiation, while it was 69% after four-hour magnetic stirring. In addition, microwave irradiation is not an efficient method for this reaction owing to the decomposition of reaction mixture at warm temperature (approx. 50 • C). The optimized conditions were used to investigate the substrate scope of the sulfinylation. Altogether ten aromatic and hetero-aromatic compounds were subjected to [Bmim]Cl·2AlCl 3 -catalysed electrophilic sulfinylation by eight alkyl alkanesulfinate/arenesulfinates under ultrasound irradiation (Tables 2 and 3).  The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).  Table 2. Influence of the nature of the alkyl alkane/arenesulfinates on the yields of asymmetrical sulfoxides a . The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).  Table 2. Influence of the nature of the alkyl alkane/arenesulfinates on the yields of asymmetrical sulfoxides a . The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).  Table 2. Influence of the nature of the alkyl alkane/arenesulfinates on the yields of asymmetrical sulfoxides a . The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).  Table 2. Influence of the nature of the alkyl alkane/arenesulfinates on the yields of asymmetrical sulfoxides a . The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).  Table 2. Influence of the nature of the alkyl alkane/arenesulfinates on the yields of asymmetrical sulfoxides a . The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).  Table 2. Influence of the nature of the alkyl alkane/arenesulfinates on the yields of asymmetrical sulfoxides a . The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).  Table 2. Influence of the nature of the alkyl alkane/arenesulfinates on the yields of asymmetrical sulfoxides a . The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).   The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).   The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).   The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).   The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).   The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).   The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2).   The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2). The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2). Table 3. Influence of the nature of the aromatic compounds on the sulfinylation using methyl benzenesulfinate a .

Entry Arene Product Time (h) Yield b (%)
1 (in hours) at room temperature; b Yield of isolated product.
The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2). The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2). The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2). The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2). The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2). The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2). The results from altering eight alkyl alkanesulfinate/arenesulfinates used for the sulfinylation of 1,3-dimethoxybenzene demonstrated that the structures of sulfinic esters have influenced the reaction conversion and yield significantly ( Table 2). Alkyl arenesulfinates appeared as better electrophiles than alkyl alkanesulfinates. It was, therefore, concluded that the aromatic ring played an important role to stabilize electrons of intermediate in the transition stage (Discussion, Scheme 2). Table 3. Influence of the nature of the aromatic compounds on the sulfinylation using methyl benzenesulfinate a .                In the next series of experiments on the influences of substituted benzene or substituted polycyclic benzenoid hydrocarbons, benzene, naphthalene and phenanthrene were selected as model substrates. The results displayed that the reactions of benzene and naphthalene with methyl benzenesulfinate did not occur, while the reaction of phenanthrene worked slowly to obtain a low yield of sulfoxide (4%) under ultrasound irradiation for three hours. Further experiments on the electrophilic sulfinylation of electron rich arenes with methyl benzenesulfinate demonstrated that sulfoxide products were obtained in moderate to good yield after much shorter reaction times Scheme 2. A plausible mechanism for the sulfinylation of aromatic compounds with alkyl arenesulfinates using [Bmim][Al 2 Cl 7 ].

Entry
In the next series of experiments on the influences of substituted benzene or substituted polycyclic benzenoid hydrocarbons, benzene, naphthalene and phenanthrene were selected as model substrates. The results displayed that the reactions of benzene and naphthalene with methyl benzenesulfinate did not occur, while the reaction of phenanthrene worked slowly to obtain a low yield of sulfoxide (4%) under ultrasound irradiation for three hours. Further experiments on the electrophilic sulfinylation of electron rich arenes with methyl benzenesulfinate demonstrated that sulfoxide products were obtained in moderate to good yield after much shorter reaction times (generally 1 h) under ultrasound irradiation, especially most sulfinyl groups were predominantly located at para position compared with the former activating substituents on aromatic substrates in order to reduce the steric hindrance (Entries 1-6, Table 3). Contrarily, a sulfinyl group was favorably occupied at the ortho position compared with hydroxyl group in order to reach a lower transition free energy and more stable product from the formation of intra-hydrogen bond between hydroxyl group and sulfinyl group (Entry 3, Table 3).
In the continuation of substrate investigation, the reactions of indole derivatives and methyl benzenesulfinate showed that the amount of sulfoxide formed from the sulfinylation of indole was obtained in a lower yield than it from the sulfinylation of 1-methylindole due to a complex formation between indole and [Bmim][Al 2 Cl 7 ] (Entries 7 and 8, Table 3).
With advantages of [Bmim][Al 2 Cl 7 ] on enhanced reactivity and mildness, the reusability of [Bmim][Al 2 Cl 7 ] was focused on for examination. The [Bmim][Al 2 Cl 7 ] collected after separation from the previous reactions was washed with diethyl ether, subsequently evaporated under reduced pressure at 80 • C for 30 min and obtained in 82% of recycled yield. The structure of recovered catalyst at the fourth recycle time was comparable with that of the fresh [Bmim][Al 2 Cl 7 ] by 1 H-NMR spectra. The recycled [Bmim][Al 2 Cl 7 ] was used for the sulfinylation of 1,3-dimethoxybezene with methyl benzenesulfinate as that of the optimized experiment presented in Entry 1, Table 2. The catalytic efficiency of [Bmim][Al 2 Cl 7 ] did not drop significantly even after three runs of being reused and recycled ( Figure 1). pressure at 80 °C for 30 min and obtained in 82% of recycled yield. The structure of recovered catalyst at the fourth recycle time was comparable with that of the fresh [Bmim][Al2Cl7] by 1 H-NMR spectra. The recycled [Bmim][Al2Cl7] was used for the sulfinylation of 1,3-dimethoxybezene with methyl benzenesulfinate as that of the optimized experiment presented in Entry 1, Table 2. The catalytic efficiency of [Bmim][Al2Cl7] did not drop significantly even after three runs of being reused and recycled (Figure 1).

Discussion
According to several previous investigations on the formation of arenesulfinyl chloride intermediates occurred reversibly from the corresponding alkyl arenesulfinates in the presence of hydrogen chloride and chloride ions [41], arenesulfinyl chlorides (A) are obviously generated and preserved under chloroaluminate-based 1-butyl-3-methylimidazole chloride (N = 0.67) owing to a large number of chloride ions. Subsequently, the formation of sulfoxide can be explained by a mechanism similar to that of the Friedel-Crafts sulfonylation of arenes [42], and the sulfenylation of indole [43]. It meant that a complex (B) of arenesulfinyl chloride with AlCl3 in [Bmim][Al2Cl7] was formed and then released sulfinyl cation (C) which was efficiently stabilized by delocalized electrons of benzene. After that, an intermediate (D) could be produced by an eletrophilic sulfinylation of electron rich arenes with sulfinyl cation. Finally, a loss of a proton from (D) produced the sulfoxide product (Scheme 2).

Instrumentation
Microwave irradiation was performed by means of a CEM Discover microwave oven produced by CEM Corporation, Matthews, NC, USA.

Discussion
According to several previous investigations on the formation of arenesulfinyl chloride intermediates occurred reversibly from the corresponding alkyl arenesulfinates in the presence of hydrogen chloride and chloride ions [41], arenesulfinyl chlorides (A) are obviously generated and preserved under chloroaluminate-based 1-butyl-3-methylimidazole chloride (N = 0.67) owing to a large number of chloride ions. Subsequently, the formation of sulfoxide can be explained by a mechanism similar to that of the Friedel-Crafts sulfonylation of arenes [42], and the sulfenylation of indole [43]. It meant that a complex (B) of arenesulfinyl chloride with AlCl 3 in [Bmim][Al 2 Cl 7 ] was formed and then released sulfinyl cation (C) which was efficiently stabilized by delocalized electrons of benzene. After that, an intermediate (D) could be produced by an eletrophilic sulfinylation of electron rich arenes with sulfinyl cation. Finally, a loss of a proton from (D) produced the sulfoxide product (Scheme 2).

Instrumentation
Microwave irradiation was performed by means of a CEM Discover microwave oven produced by CEM Corporation, Matthews, NC, USA. Ultrasound irradiation was performed by means of a BRANSON 1510 ultrasonic bath, operating at 40 kHz with a power output of 70 W. GC/MS analyses were performed on a Hewlett Packard 6890 GC series II, apparatus of MS 5975C with a triple-axis detector equipped with a J and W DB-5MS capillary column (30 m, 0.25 mm i.d., 0.25 µm film thickness) and a Hewlett Packard 7683B autosampler. LC/MS analyses were performed on a micrOTOF-QII-ESI-Qq-TOF (Bruker Daltonics, Bremen, Germany) with UV/VIS and MS detector, the heated capillary of iron trap mass spectrometer was set to 350 • C, reverse column ACE 3C18 (5 µm × 4.6 × 150 mm) and ESI (electrospray ionization): µQTOF Bruker. NMR spectra were recorded on a Brüker 500 NMR spectrometer at 500 MHz ( 1 H) and 125 MHz ( 13 C).

Chemicals
All commercially available chemicals used were from Aldrich and analyzed for authenticity and purity by GC/MS before being used.
Preparation of commercially unavailable alkyl alkanesulfinates/arenesulfinates: A solution of N-bromosuccinimide (6 mmol, 1.067 g) dissolved in methanol (5 mL) and ethyl acetate (1 mL) was added dropwise into the 25 mL two-neck round-bottom flask already containing thiol (3 mmol) in methanol (5 mL), and then 4 mL of methanol was poured additionally up to 14 mL total amount. The flask was placed into an ultrasound bath where the mixture of reactants was exposed to ultrasound irradiation for a specific period of time. Subsequently, the reaction mixture was extracted with dichloromethane (4 × 15 mL). The combined extracts were neutralized with a saturated solution of