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Molecules 2017, 22(5), 779;

Chemical Composition of Laurencia obtusa Extract and Isolation of a New C15-Acetogenin

Université de Corse-CNRS, UMR 6134 SPE, Equipe Chimie et Biomasse, Route des Sanguinaires, 20000 Ajaccio, France
CNC.IBILI/Faculty of Pharmacy, University of Coimbra, Health Sciences Campus, Azinhaga de S. Comba, 3000-548 Coimbra, Portugal
Escola Superior de Saúde Dr. Lopes Dias, Instituto Politécnico de Castelo Branco, Campus da Talagueira, 6000-767 Castelo Branco, Portugal
Plateforme d’Ingénierie et d’Analyses Moléculaires, Université d’Angers, UFR Sciences, 49000 Angers, France
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 11 April 2017 / Revised: 27 April 2017 / Accepted: 6 May 2017 / Published: 11 May 2017
(This article belongs to the Section Natural Products Chemistry)
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A new C15-acetogenin, sagonenyne (20), exhibiting an unusual single tetrahydropyran ring was isolated from an ethyl acetate extract of Laurencia obtusa collected on the Corsican coastline. Its structure was established by detailed NMR spectroscopic analysis, mass spectrometry, and comparison with literature data. Twenty-three known compounds were identified in the same extract by means of column chromatography steps, using a 13C-NMR computer aided method developed in our laboratory. In addition to sesquiterpenes, which represent the main chemical class of this extract, diterpenes, sterols, and C15-acetogenins were identified. The crude extract was submitted to a cytotoxicity assay and was particularly active against THP-1 cells, a human leukemia monocytic cell line. View Full-Text
Keywords: Laurencia obtusa; 13C-NMR; corsica; cytotoxic activity; sagonenyne Laurencia obtusa; 13C-NMR; corsica; cytotoxic activity; sagonenyne

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Esselin, H.; Sutour, S.; Liberal, J.; Cruz, M.T.; Salgueiro, L.; Siegler, B.; Freuze, I.; Castola, V.; Paoli, M.; Bighelli, A.; Tomi, F. Chemical Composition of Laurencia obtusa Extract and Isolation of a New C15-Acetogenin. Molecules 2017, 22, 779.

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