The Pharmaceutical Industry in 2016. An Analysis of FDA Drug Approvals from a Perspective of the Molecule Type

This is an analysis from a chemical point of view of the 22 drugs accepted by the FDA during 2016. The different drugs from the 2016 “harvest” have been classified according to their chemical structure: antibodies; TIDES (oligonucleotides and peptides); amino acids and natural products; drug combination; and small molecules.

. New Chemical Entities and Biologics approved by the FDA in the last two decades [3,4].
On the basis of the analysis of FDA figures in 2016, it can be concluded that the niche occupied by biologics (seven monoclonal antibodies) is growing. In this regard, 2016 (Table 1) was the third best year after 2015 (12) and 2014 (11), with biologics accounting for 32% of the total for the year, which is the highest figure in two decades. Investments in this field are increasing. In this regard, the development of antibody drug conjugates (ADCs) and proteins ensures an increase in biologics production. An analysis of the FDA data on NCEs (which until just a few years ago were primarily small molecules) for 2016 reveals that three oligonucleotides were approved ( Figure 2). Thus, the approval of Spinraza, a 18-mer antisense oligonucleotide targeting spinal muscular atrophy ( Figure 2B); Exondis 51, a 30-mer morpholino phosphorodiamidate antisense oligomer against Duchenne muscular dystrophy ( Figure 2C); and Defitelio, a mixture of oligodeoxyribonucleic acids for hepatic veno-occlusive disease ( Figure 2D), marks the advancement of these chemical species and implies a returns on the large investments made by the pharmaceutical industry in this field since the earlier 1990s. On the basis of the analysis of FDA figures in 2016, it can be concluded that the niche occupied by biologics (seven monoclonal antibodies) is growing. In this regard, 2016 (Table 1) was the third best year after 2015 (12) and 2014 (11), with biologics accounting for 32% of the total for the year, which is the highest figure in two decades. Investments in this field are increasing. In this regard, the development of antibody drug conjugates (ADCs) and proteins ensures an increase in biologics production. An analysis of the FDA data on NCEs (which until just a few years ago were primarily small molecules) for 2016 reveals that three oligonucleotides were approved ( Figure 2). Thus, the approval of Spinraza, a 18-mer antisense oligonucleotide targeting spinal muscular atrophy ( Figure 2B); Exondis 51, a 30-mer morpholino phosphorodiamidate antisense oligomer against Duchenne muscular dystrophy ( Figure 2C); and Defitelio, a mixture of oligodeoxyribonucleic acids for hepatic veno-occlusive disease ( Figure 2D), marks the advancement of these chemical species and implies a returns on the large investments made by the pharmaceutical industry in this field since the earlier 1990s. Other TIDES (oligo-pep-TIDES) approved this year include Adlyxin, a 44-amino acid peptide antidiabetic ( Figure 3), with a molecular weight of 4858 that belongs to the family of glucagon-like peptide-1 (GLP-1) agonist. Specifically, Adlyxin is derived from exendin-4, where the Pro at the C-terminal has been removed and a linker of Lys6 ( Figure 3, highlighted Blue) has been added instead [6]. These four biomolecules are a clear example of the power of solid-phase synthesis for the industrial production of TIDES-based Active Pharmaceutical Ingredients (APIs). Only a few years ago, the pharmaceutical industry was reluctant to consider peptides and oligonucleotides of this size as potential drugs, because of the lack of reliable chemical strategies for their preparation. However, the synthetic advances using the solid-phase methodology now makes the production of these large TIDES-based APIs feasible.
Briviact (epilepsy) is a compound derived from the amino acid α-ethylglycinamide ( Figure 4B, blue). Continuing with amino acids, Alumni is an α,α-disubstitutedglycine ( Figure 4C, blue) bearing an 18 F atom and used as a diagnostic agent in positron emission tomography (PET) imaging for prostate cancer. In this same class, Netspot has been approved as a kit for the preparation of 68 Ga dotatate injection for PET scans. In the field of natural product-based drugs, Ocaliva (primary biliary cholangitis), which is a semisynthetic bile acid, has been also approved ( Figure 4D).  Other TIDES (oligo-pep-TIDES) approved this year include Adlyxin, a 44-amino acid peptide antidiabetic (Figure 3), with a molecular weight of 4858 that belongs to the family of glucagon-like peptide-1 (GLP-1) agonist. Specifically, Adlyxin is derived from exendin-4, where the Pro at the C-terminal has been removed and a linker of Lys6 (Figure 3, highlighted Blue) has been added instead [6]. These four biomolecules are a clear example of the power of solid-phase synthesis for the industrial production of TIDES-based Active Pharmaceutical Ingredients (APIs). Only a few years ago, the pharmaceutical industry was reluctant to consider peptides and oligonucleotides of this size as potential drugs, because of the lack of reliable chemical strategies for their preparation. However, the synthetic advances using the solid-phase methodology now makes the production of these large TIDES-based APIs feasible.
Briviact (epilepsy) is a compound derived from the amino acid α-ethylglycinamide ( Figure 4B, blue). Continuing with amino acids, Alumni is an α,α-disubstitutedglycine ( Figure 4C, blue) bearing an 18 F atom and used as a diagnostic agent in positron emission tomography (PET) imaging for prostate cancer. In this same class, Netspot has been approved as a kit for the preparation of 68 Ga dotatate injection for PET scans. In the field of natural product-based drugs, Ocaliva (primary biliary cholangitis), which is a semisynthetic bile acid, has been also approved ( Figure 4D). These four biomolecules are a clear example of the power of solid-phase synthesis for the industrial production of TIDES-based Active Pharmaceutical Ingredients (APIs). Only a few years ago, the pharmaceutical industry was reluctant to consider peptides and oligonucleotides of this size as potential drugs, because of the lack of reliable chemical strategies for their preparation. However, the synthetic advances using the solid-phase methodology now makes the production of these large TIDES-based APIs feasible.
Briviact (epilepsy) is a compound derived from the amino acid α-ethylglycinamide ( Figure 4B, blue). Continuing with amino acids, Alumni is an α,α-disubstitutedglycine ( Figure 4C, blue) bearing an 18 F atom and used as a diagnostic agent in positron emission tomography (PET) imaging for prostate cancer. In this same class, Netspot has been approved as a kit for the preparation of 68 Ga dotatate injection for PET scans. In the field of natural product-based drugs, Ocaliva (primary biliary cholangitis), which is a semisynthetic bile acid, has been also approved ( Figure 4D). Zepatier ( Figure 5A) and Epclusa ( Figure 5B) are two two-drug combinations for the treatment of hepatitis C. Both contains a hepatitis C virus NSSA inhibitor (Elbasvir and Velpatasvir, respectively) and Grazopevir (macrocycle, NS3/4A protease inhibitor) and Sofosbuvir (nucleotide, viral RNA polymerase inhibitor), respectively.  Zepatier ( Figure 5A) and Epclusa ( Figure 5B) are two two-drug combinations for the treatment of hepatitis C. Both contains a hepatitis C virus NSSA inhibitor (Elbasvir and Velpatasvir, respectively) and Grazopevir (macrocycle, NS3/4A protease inhibitor) and Sofosbuvir (nucleotide, viral RNA polymerase inhibitor), respectively. Zepatier ( Figure 5A) and Epclusa ( Figure 5B) are two two-drug combinations for the treatment of hepatitis C. Both contains a hepatitis C virus NSSA inhibitor (Elbasvir and Velpatasvir, respectively) and Grazopevir (macrocycle, NS3/4A protease inhibitor) and Sofosbuvir (nucleotide, viral RNA polymerase inhibitor), respectively.  The last four compounds: Rubraca an indole derivative for the treatment of patients with deleterious BRCA mutation associated to ovarian cancer ( Figure 6A); Eucrisa, a hemiboronate for atopic dermatitis ( Figure 6B); Nuplazid, which acts in some psychotic disorders in Parkinson's disease, and is a trisubstituted urea ( Figure 6C); and Venclexta, a complex sulfonamide used in the treatment of chronic lymphocytic leukaemia ( Figure 6D), are those that best fit the small molecule category, although the last one has a molecular weight of 868. The last four compounds: Rubraca an indole derivative for the treatment of patients with deleterious BRCA mutation associated to ovarian cancer ( Figure 6A); Eucrisa, a hemiboronate for atopic dermatitis ( Figure 6B); Nuplazid, which acts in some psychotic disorders in Parkinson's disease, and is a trisubstituted urea ( Figure 6C); and Venclexta, a complex sulfonamide used in the treatment of chronic lymphocytic leukaemia ( Figure 6D), are those that best fit the small molecule category, although the last one has a molecular weight of 868. In conclusion, while the number of drugs approved by the FDA in 2016 was smaller than expected, taking into account preceding years, they show great diversity from a chemical point of view. In this regard, the most important highlight is probably the presence of the three oligonucleotides, which are expected to open up new avenues for this key category of biomolecule. Advances in the solid-phase methodology for the preparation of large TIDES are driving the development of these kinds of biomolecule as APIs [7]. The approval of seven monoclonal antibodies is also worth noting. There is no doubt that this class of biologics is the most suitable for the treatment of hitherto intractable diseases. More ADCs are expected to be approved in the coming years, thus positioning antibodies as first class pharmaceuticals. The outputs from 2016 indicate the so-called small molecules are losing ground against biologics, biomolecules, and other molecules inspired on natural products. However, the ultimate aim of any drug, regardless of the chemical species, is to bring relief to those suffering. If this is achieved, many will benefit. In conclusion, while the number of drugs approved by the FDA in 2016 was smaller than expected, taking into account preceding years, they show great diversity from a chemical point of view. In this regard, the most important highlight is probably the presence of the three oligonucleotides, which are expected to open up new avenues for this key category of biomolecule. Advances in the solid-phase methodology for the preparation of large TIDES are driving the development of these kinds of biomolecule as APIs [7]. The approval of seven monoclonal antibodies is also worth noting. There is no doubt that this class of biologics is the most suitable for the treatment of hitherto intractable diseases. More ADCs are expected to be approved in the coming years, thus positioning antibodies as first class pharmaceuticals. The outputs from 2016 indicate the so-called small molecules are losing ground against biologics, biomolecules, and other molecules inspired on natural products. However, the ultimate aim of any drug, regardless of the chemical species, is to bring relief to those suffering. If this is achieved, many will benefit. Acknowledgments: The work performed by the authors is funded by the National Research Foundation (NRF) and the University of KwaZulu-Natal.
Author Contributions: Both authors have written the paper.

Conflicts of Interest:
The authors declare no conflict of interest.