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Molecules 2015, 20(8), 14879-14888;

Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Nanjing Sanhome Pharmaceutical Co., Ltd., Nanjing 210018, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 24 May 2015 / Revised: 13 July 2015 / Accepted: 22 July 2015 / Published: 14 August 2015
(This article belongs to the Section Natural Products Chemistry)
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A new skeleton of diterpenoid, 1,2,3,4,4α,9,10,10α-octahydro-(4α-hydroxyymethyl) -1,1-dimethyl-9-(1-methylethyl)-(2S,3S,4αR,9R,10αS)-2,3,5,7-phenanthrenetertrol, named plebeianiol A (1), along with four known diterpenoids (25), were isolated from Salvia plebeia R. Br. Their structures were determined on the basis of spectral analysis. In the bioactivity tests, compounds 1, 2 and 5 showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities with IC50 values of 20.0–29.6 µM. In addition, these three compounds had significant inhibitory effects on reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-induced macrophages. Compounds 13 inhibited nitric oxide (NO) production in LPS-induced macrophages with IC50 values of 18.0–23.6 µM. These results showed that compounds 1, 2 had significant antioxidant and anti-inflammatory activities and might provide basis for the treatment of diseases associated with oxidative lesions and inflammation. View Full-Text
Keywords: Salvia plebeia; diterpenoids; antioxidant activity; anti-inflammatory activity Salvia plebeia; diterpenoids; antioxidant activity; anti-inflammatory activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zhang, B.-B.; He, B.-Q.; Sun, J.-B.; Zeng, B.; Shi, X.-J.; Zhou, Y.; Niu, Y.; Nie, S.-Q.; Feng, F.; Liang, Y.; Wu, F.-H. Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities. Molecules 2015, 20, 14879-14888.

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