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Molecules
Volume 20
Issue 8
10.3390/molecules200814879
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Article

Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities

by
Bao-Bao Zhang
1,†,
Bai-Qiu He
1,†,
Jian-Bo Sun
1,
Biao Zeng
1,
Xiao-Ji Shi
1,
Yong Zhou
1,
Ying Niu
1,
Shi-Qi Nie
1,
Feng Feng
1,
Yan Liang
2,* and
Fei-Hua Wu
1,*
1
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
2
Nanjing Sanhome Pharmaceutical Co., Ltd., Nanjing 210018, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(8), 14879-14888; https://doi.org/10.3390/molecules200814879
Received: 24 May 2015 / Revised: 13 July 2015 / Accepted: 22 July 2015 / Published: 14 August 2015
(This article belongs to the Section Natural Products Chemistry)
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Abstract

A new skeleton of diterpenoid, 1,2,3,4,4α,9,10,10α-octahydro-(4α-hydroxyymethyl) -1,1-dimethyl-9-(1-methylethyl)-(2S,3S,4αR,9R,10αS)-2,3,5,7-phenanthrenetertrol, named plebeianiol A (1), along with four known diterpenoids (2–5), were isolated from Salvia plebeia R. Br. Their structures were determined on the basis of spectral analysis. In the bioactivity tests, compounds 1, 2 and 5 showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities with IC50 values of 20.0–29.6 µM. In addition, these three compounds had significant inhibitory effects on reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-induced macrophages. Compounds 1–3 inhibited nitric oxide (NO) production in LPS-induced macrophages with IC50 values of 18.0–23.6 µM. These results showed that compounds 1, 2 had significant antioxidant and anti-inflammatory activities and might provide basis for the treatment of diseases associated with oxidative lesions and inflammation. View Full-Text
Keywords: Salvia plebeia; diterpenoids; antioxidant activity; anti-inflammatory activity Salvia plebeia; diterpenoids; antioxidant activity; anti-inflammatory activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

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MDPI and ACS Style

Zhang, B.-B.; He, B.-Q.; Sun, J.-B.; Zeng, B.; Shi, X.-J.; Zhou, Y.; Niu, Y.; Nie, S.-Q.; Feng, F.; Liang, Y.; Wu, F.-H. Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities. Molecules 2015, 20, 14879-14888. https://doi.org/10.3390/molecules200814879

AMA Style

Zhang B-B, He B-Q, Sun J-B, Zeng B, Shi X-J, Zhou Y, Niu Y, Nie S-Q, Feng F, Liang Y, Wu F-H. Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities. Molecules. 2015; 20(8):14879-14888. https://doi.org/10.3390/molecules200814879

Chicago/Turabian Style

Zhang, Bao-Bao, Bai-Qiu He, Jian-Bo Sun, Biao Zeng, Xiao-Ji Shi, Yong Zhou, Ying Niu, Shi-Qi Nie, Feng Feng, Yan Liang, and Fei-Hua Wu. 2015. "Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities" Molecules 20, no. 8: 14879-14888. https://doi.org/10.3390/molecules200814879

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