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Molecules 2014, 19(7), 8916-8932; https://doi.org/10.3390/molecules19078916

Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities

1,†
,
2,†
,
1
and
1,*
1
Department of Chirurgery, First Affiliated Hospital of Anhui Medical University, Hefei 230032, China
2
Department of Chemistry, Anhui Medical University, Hefei 230032, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 23 April 2014 / Revised: 15 June 2014 / Accepted: 18 June 2014 / Published: 26 June 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migration of human umbilical vein endothelial cells (HUVECs). Among these compounds, 11d was the most potent agent, that also exhibited the highest anti-angiogenesis activities in the chick embryo chorioallantoic membrane (CAM) assay. View Full-Text
Keywords: 2,4-disubstituted quinazoline derivatives; synthesis; anti-angiogenesis 2,4-disubstituted quinazoline derivatives; synthesis; anti-angiogenesis
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Yu, G.; Li, Z.; Tang, L.; Xiong, Q. Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities. Molecules 2014, 19, 8916-8932.

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