Palladium-Catalyzed Multicomponent Synthesis of 2-Imidazolines from Imines and Acid Chlorides

We describe the palladium-catalyzed multicomponent synthesis of 2-imidazolines. This reaction proceeds via the coupling of imines, acid chlorides and carbon monoxide to form imidazolinium carboxylates, followed by a decarboxylation. Decarboxylation in CHCl3 is found to result in a mixture of imidazolinium and imidazolium salts. However, the addition of benzoic acid suppresses aromatization, and generates the trans-disubstituted imidazolines in good yield. Combining this reaction with subsequent nitrogen deprotection provides an overall synthesis of imidazolines from multiple available building blocks.

The traditional method to synthesize imidazolines involves the coupling of a 1,2-diamine with an appropriate condensation partner, such as aldehydes, esters, amides or imidates [14][15][16][17][18]. More recently, other synthetic routes to imidazolines have been reported, including the ring opening of aziridines [19,20], the reaction of imines with isocyanates [21][22][23], and the cycloaddition of imines to OPEN ACCESS azomethine ylides [24]. While these methods are each effective, they often require the use of synthetic precursors which can themselves require a multistep synthesis. This can make it challenging to both generate polysubstituted imidazolines, and to diversify their structure to modify properties.
We have previously reported a palladium-catalyzed multicomponent synthesis of imidazolinium carboxylates from imines, acid chlorides and CO (Scheme 1) [25][26][27]. Transition-metal catalyzed multicomponent reactions have emerged as a powerful tool in synthesis as they can allow the controlled assembly of multiple simple units directly into complex products [28][29][30][31][32][33]. The generation of 1 proceeds via imine cycloaddition to an in situ generated münchnone (Scheme 1). This reactivity is similar to alkene cycloaddition to münchnones, which, upon themolysis, can undergo decarboxylation to yield pyrrolines [34,35]. As such, we became interested in the analogous reaction of 1. The latter could provide a modular assembly of imidazolines. Tepe and co-workers have recently reported that similar 2-imidazoline carboxylates can undergo thermal decarboxylation under certain conditions [36]. This observation prompted us to investigate decarboxylation as a platform to access substituted imidazolines from 1. Scheme 1. Palladium catalyzed synthesis of imidazolinium carboxylates.

Results and Discussion
In order to test the viability of this chemistry in imidazoline synthesis, imidazolinium carboxylate 1a (R 1 , R 4 = benzyl, R 2 , R 3 , R 5 = phenyl) was prepared via the palladium catalyzed multicomponent synthesis shown in Scheme 1 [JOHNPHOS = P(t-Bu) 2 (2-biphenyl)]. The heating of 1a in CDCl 3 at 65 °C for 6 h leads to the complete conversion of starting compound and the formation of three products, identified as the trans-and cis-isomers of the imidazolinium 2a, as well as the aromatized imidazolium 3a in yields of 59:16:13, respectively (Scheme 2) [37]. The thermal decarboxylation of 1a presumably proceeds via the initial loss of CO 2 to generate the ylide 1a', which could either be protonated by the solvent (compound 2a) or undergo oxidation to form 3a. To favor the generation of 2a, we examined the influence of acids on the reaction. As shown in Table 1, performing the decarboxylation with one equivalent of benzoic acid leads to the exclusive formation of the imidazoline in 78% yield (entry 1). Other organic carboxylic acids are also effective, and result in similar yields and selectivities (entries 2-3). In all cases, no significant amount of aromatized product 3a is observed, indicating a rapid protonation of the ylide intermediate. The use of stronger acids did not lead to decarboxylation (entries 4-6). In addition, the use of a large excess of benzoic acid inhibited the reaction (entry 7). This suggests that the decarboxylation occurs from zwitterionic 1a.
The above reactions all generate imidazolium salt 2a as a mixture of stereoisomers. However, during our studies on this decarboxylation, we were surprised to find that the use of wet chloroform solvent significantly favored the generation of trans-2a over the cis-isomer. This can be performed in a more controlled fashion, where the addition of an excess of water (20 equiv.) with benzoic acid leads to the formation of trans-2a in 86% yield, and almost completely suppresses the cis-product (entry 8). The mechanism by which water influences the protonation is not known, although a control experiment using water without acid leads to decomposition of the starting material (entry 9), suggesting water in concert with benzoic acid results in a proton source that favors proton transfer on the same face as the pendant aromatic unit.
This sequence of palladium catalyzed multicomponent coupling and decarboxylation provides a method to selectively generate trans-substituted imidazolinium salts. As imines are readily available from aldehydes and amines, it is straightforward to synthesize asymmetrically substituted imidazolines. This can include the incorporation of orthogonal nitrogen protecting groups. For example, imidazolinium carboxylate 1b bearing both N-allyl and N-para-methoxybenzyl (PMB) protecting groups can be generated through palladium catalysis (Scheme 3). Subsequent decarboxylation followed by deallylation yields imidazoline 4b. Alternatively, the para-methoxybenzyl group can be cleaved from imidazolinium cation 2b, affording imidazoline 5b. As an illustration of the versatility of this approach, a number of orthogonally substituted imidazolines have been generated via the palladium catalyzed synthesis of 1 and selective decarboxylation (Scheme 4). The substituents of the imidazoline core can be varied by choosing the appropriate imine(s) and acid chloride, while functional groups such as esters, aryl ethers, alkenes and aryl-halides are all tolerated. This modularity can allow for the rapid synthesis of imidazolines with independent control of four separate substituents.

General Considerations
All solvents used were dried by passage through a column of alumina prior to use. All common reagents were purchased from Aldrich (Oakville, Canada) and used as received unless otherwise noted. Pd(PPh 3 ) 4 was purchased from Strem (Boston, MA, USA) and stored in a nitrogen glovebox. Imines were synthesized by the condensation of the appropriate aldehyde and amine in the presence of MgSO 4 and purified by distillation under vaccum, according literature methods [38]. Amide-chelated palladium catalysts were synthesized according to a literature protocol [39]. N,N-diisopropylethylamine was distilled over CaH 2 prior to use. Carbon monoxide was purchased at 99.99% purity MEGS (Montreal, Canada) and used as received. NMR characterization was performed at 300 MHz, 400 MHz and 500 MHz for 1 H-NMR and 75 MHz and 126 MHz for 13 C-NMR on Varian spectrometers. Resonances at 145.5 and 53.2 ppm in the 13 C-NMR spectra are artifacts generated during data collection and do not represent real product signals. Chemical shifts are reported in parts per million relative to the residual solvent signal. Mass spectra were recorded on a Agilent LC-MSD TOF high-resolution electrospray ionization quadrupole spectrometer.
To a sample of 1b (50.2 mg, 0.100 mmol), was added benzoic acid (12.2 mg, 0.100 mmol) in CHCl 3 (5 mL). Water (36 μL, 2 mmol) was added by micropipette and the vial was capped and heated at 65 °C for 6 h. The mixture was allowed to cool to room temperature, diluted with CH 2 Cl 2 (20 mL), then washed with brine, extracting with additional CH 2 Cl 2 . The combined organic layers were dried with Na 2 SO − 4 , filtered and concentrated to give imidazolinium 2b as a yellow solid. This compound was transferred without further purification to a dry Schlenk flask and placed under N 2 . Pd(PPh 3 ) 4 (11.5 mg, 0.010 mmol) was added as a solution in dry CH 2 Cl 2 (2 mL) followed by PhSiH 3 (25.0 μL, 0.2 mmol) in CH 2 Cl 2 (2 mL). The reaction mixture was allowed to stir at room temperature for 16 h. The solution was then diluted with additional with CH 2 Cl 2 (20 mL) and washed with brine, extracting with additional CH 2 Cl 2 . The organic layers were dried with Na 2 SO − 4 , filtered and concentrated to give a brown solid which was purified by flash column chromatography (5% MeOH in CH 2 Cl 2 ) to yield imidazoline 4b as a brown solid (31.9 mg, 76% dr: 13:1) 1

Synthesis of 1-Allyl-2,4,5-triphenyl-4,5-dihydro-1H-imidazole (5b)
Compound 2b (95.6 mg, 0.19 mmol) was prepared as described above, and transferred without further purification to a dry Schlenk flask and placed under N 2 . The solid was dissolved in dry CH 2 Cl 2 (5 mL) and cooled to 0 °C. BBr 3 (1.0 M in CH 2 Cl 2 , 2 mL, 2 mmol, 10 equiv.) was added slowly and the mixture was allowed to warm to room temperature. The solution was stirred at room temperature for 2 h. Sodium hydroxide (10 mL 1.0M solution) was rapidly added to the solution, which was then diluted with CH 2 Cl 2 (20 mL), and washed with brine, extracting with additional CH 2 Cl 2 . The organic layers were dried with Na 2 SO − 4 , filtered, and concentrated to give a yellow oil which was purified by flash column chromatography (5% MeOH in CH 2 Cl 2 ) to give a imidazoline 5b as a yellow oil