Cesium Carbonate-Catalyzed α-Phenylchalcogenation of Carbonyl Compounds with Diphenyl Dichalcogenide

It was found that cesium carbonate has a unique catalytic ability on the reaction of carbonyl compounds with diphenyl diselenide to give the corresponding α-phenylseleno carbonyl compounds in moderate to good yields. Similarly, the α-phenylthiolation of carbonyl compounds with diphenyl disulfide was promoted by the cesium carbonate catalyst.


Results and Discussion
When 5-nonanone (1a; 0.30 mmol) was allowed to react with an equivalent amount of diphenyl diselenide (0.30 mmol) in the presence of a catalytic amount of cesium carbonate (0.05 mmol, 17 mol%) in DMA solvent at 70 °C for 5 h, the α-phenylselenation of 1a smoothly proceeded to give 4-phenylseleno-5-nonanone (2a) in 0.03 mmol yield (entry 2 in Table 1). In the absence of the cesium salt, 2a was not formed and the starting materials were recovered (entry 1). Increasing the amount of 1a, extending the reaction time, and elevating the reaction temperature led to the increase the yield of 2a (entries 2-7). When diphenyl diselenide was treated with ten equivalent amounts of 1a (3.00 mmol) under air at 100 °C for 5 h, 2a was obtained in 0.59 mmol yield, along with a formation of a small amount of 4,4-bisphenylseleno-5-nonanone (entry 7). It is interested to note that both phenylseleno groups on diphenyl diselenide are efficiently utilized on the reaction. When the reaction was carried out under a nitrogen atmosphere, the yield of 2a was decreased (entry 8). Similarly, in the presence of a catalytic amount of cesium fluoride, the α-phenylselenation of 1a occurred to give 2a in 0.42 mmol yield (entry 9). In contrast to cesium carbonate and fluoride, in the case of the other cesium salts, such as cesium chloride, bromide and iodide, the α-phenylselenation did not proceed (entries 10-12). In the presence of another alkaline metal carbonates, the yields of 2a decreased slightly (entries 13 and 14) [29].
To determine the scope and limitation of the cesium salt-catalyzed α-phenylselenation of carbonyl compounds with diphenyl diselenide, various carbonyl compounds were allowed to react with diphenyl diselenide in the presence of a catalytic amount of cesium carbonate (17 mol%) and these results are shown in Table 2. The treatment of cyclohexanone with diphenyl diselenide under the same reaction conditions as that of 5-nonanone afforded 2-phenylselenocyclohexanone in 0.43 mmol yield (entry 2). For the reaction of the acetophenone and propiophenone, which have an aromatic ring adjacent to the carbonyl group, the α-phenylselenation of these compounds took place smoothly to give the corresponding α-phenylselenoacetophenone and -propiophenone in 0.51 and 0.59 mmol yields, respectively (entries 4 and 8).
4'-Methyl-, 4'-methoxy-, and 4'-chloro-α-phenylselenoacetophenone were prepared by the cesium carbonate-catalyzed reaction of the corresponding acetophenone derivatives with diphenyl diselenide in moderate to good yields (entries 5-7). When an unsymmetrical dialkyl ketone such as 2-octanone was treated with diphenyl diselenide in the presence of cesium carbonate, the phenylselenation of methylene carbon predominantly proceeded to give 3-phenylseleno-2-octanone in 0.41 mmol yield with the formation of 1-phenylseleno-2-octanone (0.17 mmol) (entry 3). In the case of hexanal, the yield of α-phenylselenoaldehyde was low (0.13 mmol) under the same reaction conditions as that of 5nonanone, owing to the formation of a complex reaction mixture that included the aldol type products; however, the α-phenylselenated product yield was improved, when the reaction was carried out under the lower reaction temperature (65 °C) (entry 9).
Next, the cesium carbonate-catalyzed reaction of carbonyl compounds with diphenyl disulfide was examined (Table 3). When 5-nonanone (3.0 mmol) was allowed to react with diphenyl disulfide (1.0 mmol) in the presence amount of cesium carbonate at 100 °C for 5 h, the α-phenylthiolation of 5nonanone was successfully occurred and 4-phenylthio-5-nonanone was obtained in 0.44 mmol yield (entry 1). The treatment of cyclohexanone or acetophenone with diphenyl disulfide also afforded the αphenylthioketone in 0.60 or 0.51 mmol yields (entries 2 and 3).  Although we cannot explain the reaction pathway of the carbonyl compounds with diphenyl diselenide in the presence of cesium carbonate catalyst in detail, one possible reaction pathway is shown in Scheme 2. The first step of the reaction is the generation of the enolate anion by the deprotonation of carbonyl compound with the cesium salt [30]. The enolate anion was trapped with diselenide to form α-phenylselenocarbonyl compounds, and the phenylselenolate [31]. When the reaction was carried out under air, the product yield was higher than when performed under a nitrogen atmosphere (entries 7 and 8 in Table 1). From the result, it was suggested that phenylselenolate was oxidized by oxygen to form phenylseleno radical and subsequently dimerized giving the diphenyl diselenide. In summary, we found a unique catalytic ability of cesium carbonate in the reaction of carbonyl compounds with diphenyl dichalogenides. The α-phenylchalcogenation of carbonyl compounds with diphenyl dichalcogenides, such as the diselenide or disulfide in the presence of cesium carbonate catalyst efficiently proceeded to give the α-phenylchalcogenocarbonyl compounds in moderate to good yields.

General
The 1 H-and 13 C-NMR spectra were recorded on a JEOL AL400 spectrometer using CDCl 3 as the solvent with tetramethylsilane as the internal standard. The IR spectra were recorded with a PerkinElmer FT-IR2000 spectrometer. Gas chromatography (GC) was performed on a Shimadzu GC-14B gas chromatograph using a flame-ionizing detector-equipped instrument and a CBP1 capillary column (0.25 mm × 1200 mm). Preparative HPLC separation was undertaken with a JAI LC-908 chromatograph using 600-mm × 20-mm JAIGEL-1H and 2H GPC columns with CHCl 3 as an eluent.

Reagents
Diphenyl disulfide, carbonyl compounds, cesium salts, and alkaline metal salts were purchased as high grade products, and used without purfication. Diphenyl diselenide was synthesized as described in the literature [22]. The solvents were purified before use by the usual methods.

General procedure for cesium salt-catalyzed reaction of carbonyl componds with diphenyl diselenide
A DMA (2.5 mL) solution of diphenyl diselenide (94 mg, 0.30 mmol), carbonyl compound (3.00 mmol), and cesium carbonate (16 mg, 0.05 mmol) was stirred at 100 °C for 5 h under air. After the reaction was complete, H 2 O was added to the reaction mixture and extracted with diisopropyl ether. The organic layer was dried over MgSO 4 . The resulting mixture was filtered, and the filtrate was concentrated. Purification of the residue by HPLC afforded the corresponding α-phenylselenated product. The product was characterized by comparing its spectral date with those of authentic samples (2a [32], 2b [27], 2d [24], 2e [24], 2f [24], 2g [24], 2h [24], and 2i [27]). The structures of the product were assigned by their 1 H-and 13 C-NMR, IR, and Mass spectra.

General procedure for cesium salt-catalyzed reaction of carbonyl compounds with diphenyl disulfide
A DMA (2.5 mL) solution of diphenyl disulfide (218 mg, 1.0 mmol), carbonyl compound (3.0 mmol), and cesium carbonate (64 mg, 0.2 mmol) was stirred at 100 °C for 5 h under air. After the reaction was complete, H 2 O was added to the reaction mixture and extracted with diisopropyl ether. The organic layer was dried over MgSO 4 . The resulting mixture was filtered, and the filtrate was concentrated. Purification of the residue by HPLC afforded the corresponding α-phenylselenated product. The product was characterized by comparing its spectral date with those of authentic samples (3a [32], 3b [33], and 3c [34]). The structures of the product were assigned by their 1 H-and 13 C-NMR, IR, and Mass spectra.