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Open AccessCommentary

Can Bioactive Lipid Arachidonic Acid Prevent and Ameliorate COVID-19?

1
UND Life Sciences, 2221 NW 5th St, Battle Ground, WA 98604, USA
2
BioScience Research Centre and Department of Medicine, GVP Medical College and Hospital, Visakhapatnam 530048, India
Medicina 2020, 56(9), 418; https://doi.org/10.3390/medicina56090418
Received: 16 July 2020 / Revised: 14 August 2020 / Accepted: 18 August 2020 / Published: 19 August 2020
(This article belongs to the Special Issue Essential Fatty Acids or Bioactive Lipids in Health and Disease)
It is proposed that the bioactive lipid, arachidonic acid (AA, 20:4 n-6), can inactivate severe acute respiratory syndrome(SARS-CoV-2), facilitate M1 and M2 macrophage generation, suppress inflammation, prevent vascular endothelial cell damage, and regulate inflammation resolution processes based on the timely formation of prostaglandin E2 (PGE2) and lipoxin A4 (LXA4) based on the context. Thus, AA may be useful both to prevent and manage coronavrus disease-2019(COVID-19). View Full-Text
Keywords: COVID-19; SARS-CoV-2; arachidonic acid; lipoxin A4; inflammation; prostaglandin E2 COVID-19; SARS-CoV-2; arachidonic acid; lipoxin A4; inflammation; prostaglandin E2
MDPI and ACS Style

Das, U.N. Can Bioactive Lipid Arachidonic Acid Prevent and Ameliorate COVID-19? Medicina 2020, 56, 418.

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