Next Article in Journal
Dupuytren’s Contracture: Incidence of Injury-Induced Cases and Specific Clinical Expression
Previous Article in Journal
Acceleration of Skin Wound-Healing Reactions by Autologous Micrograft Tissue Suspension
Open AccessReview

Prognostic Significance of ADAM17 for Gastric Cancer Survival: A Meta-Analysis

Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
College of Public Health, Hainan Medical University, Haikou 571199, China
Author to whom correspondence should be addressed.
Medicina 2020, 56(7), 322;
Received: 27 May 2020 / Revised: 14 June 2020 / Accepted: 25 June 2020 / Published: 29 June 2020
Background and objectives: The prognostic role of a disintegrin and metalloproteinase (ADAM) 17 has been widely assessed in gastric cancer. However, the results are inconsistent. We performed a meta-analysis to evaluate the prognostic significance of ADAM17 and its association with clinicopathological parameters. Methods: The databases of PubMed, Web of Science, and Embase were searched for relevant articles published up to April 2020. The reported hazard ratios (HRs) and odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were pooled to evaluate the strength of the association. Stata 12.1 was used to perform statistical analyses. Results: Seven studies, including 1757 patients, were screened for the meta-analysis. Compared with the high ADAM17 expression group, the pooled HR was higher in the low ADAM17 expression group (HR = 2.04, 95% CI 1.66–2.50; I2 = 18.1%; p = 0.299). High ADAM17 expression was also related to the tumor node metastasis (TNM) stages (OR = 4.09, 95% CI 1.85–9.04; I2 = 84.1%; p = 0.000), lymph node metastasis (OR = 3.08, 95% CI 1.13–8.36; I2 = 79.7%; p = 0.007), and ages (OR = 1.65, 95% CI 1.24–2.21; I2 = 0%; p = 0.692) of the gastric patients. Conclusions: This meta-analysis revealed that ADAM17 is a significant biomarker for poor prognosis in gastric cancer. View Full-Text
Keywords: ADAM17; gastric cancer; prognosis; meta-analysis ADAM17; gastric cancer; prognosis; meta-analysis
Show Figures

Figure 1

MDPI and ACS Style

Ni, P.; Yu, M.; Zhang, R.; He, M.; Wang, H.; Chen, S.; Duan, G. Prognostic Significance of ADAM17 for Gastric Cancer Survival: A Meta-Analysis. Medicina 2020, 56, 322.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop