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Pharmacological Interactions in the Elderly

Department of Occupational, Metabolic and Internal Diseases, Medical University of Gdańsk, 81-519 Gdynia, Poland
Department of Preventive Medicine & Education, Medical University of Gdańsk, 80-210 Gdańsk, Poland
Author to whom correspondence should be addressed.
Medicina 2020, 56(7), 320;
Received: 17 May 2020 / Revised: 22 June 2020 / Accepted: 25 June 2020 / Published: 28 June 2020
(This article belongs to the Section Geriatrics/Aging)
Pharmacological therapy in the elderly is particularly complicated and challenging. Due to coexistence of three main predisposing factors (advanced age, multiple morbidity and polypharmacotherapy), this group of patients is prone to occurrence of drug interactions and adverse effects of incorrect drug combinations. Since many years patient safety during the treatment process has been one of key elements for proper functioning of healthcare systems around the world, thus different preventive measures have been undertaken in order to counteract factors adversely affecting the therapeutic effect. One of the avoidable medical errors is pharmacological interactions. According to estimates, one in six elderly patients may be at risk of a significant drug interaction. Hence the knowledge about mechanisms and causes of drug interactions in the elderly, as well as consequences of their occurrence are crucial for planning the process of pharmacotherapy. For the purpose of pharmacovigilance, a review of available methods and tools gives an insight into possible ways of preventing drug interactions. Additionally, recognizing the actual scale of this phenomenon in geriatric population around the world emphasizes the importance of a joint effort among medical community to improve quality of pharmacotherapy. View Full-Text
Keywords: geriatrics; aging; drug interactions; medication errors/prevention and control; polypharmacy; multimorbidity geriatrics; aging; drug interactions; medication errors/prevention and control; polypharmacy; multimorbidity
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MDPI and ACS Style

Błeszyńska, E.; Wierucki, Ł.; Zdrojewski, T.; Renke, M. Pharmacological Interactions in the Elderly. Medicina 2020, 56, 320.

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