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A Comprehensive Analysis of Clinical Trials in the COVID-19 Pandemic Era

1
Department of Psychiatry, Yonsei University, Wonju College of Medicine, Wonju Kangwon 26426, Korea
2
Department of Nephrology, Yonsei University, Wonju College of Medicine, Wonju Kangwon 26426, Korea
3
Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O. Box 8044, Seoul 03722, Korea
4
Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, 6020 Innsbruck, Austria
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Medicina 2020, 56(6), 315; https://doi.org/10.3390/medicina56060315
Received: 19 May 2020 / Revised: 18 June 2020 / Accepted: 23 June 2020 / Published: 26 June 2020
Background and objective: Despite medical advances, we are facing the unprecedented disaster of the coronavirus disease 2019 (COVID-19) pandemic without available treatments and effective vaccines. As the COVID-19 pandemic has approached its culmination, desperate efforts have been made to seek proper treatments and response strategies, and the number of clinical trials has been rapidly increasing. In this time of the pandemic, it is believed that learning lessons from it would be meaningful in preparing for future pandemics. Thus, this study aims at providing a comprehensive landscape of COVID-19 related clinical trials based on the ClinicalTrials.gov database. Materials and methods: Up to 30 March 2020, we identified a total of 147 eligible clinical trials and reviewed the overview of the studies. Results: Until then, the most clinical trials were set up in China. Treatment approaches are the most frequent purpose of the registered studies. Chloroquine, interferon, and antiviral agents such as remdesivir, lopinavir, and ritonavir are agents under investigation in these trials. Conclusions: In this study, we introduced the promising therapeutic options that many researchers and clinicians are interested in, and to address the hidden issues behind clinical trials in this COVID-19 pandemic. View Full-Text
Keywords: COVID-19; clinical trials COVID-19; clinical trials
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Lee, J.; Shin, H.W.; Lee, J.Y.; Kim, J.S.; Yang, J.W.; Lee, K.H.; Kronbichler, A.; Shin, J.I. A Comprehensive Analysis of Clinical Trials in the COVID-19 Pandemic Era. Medicina 2020, 56, 315.

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