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Open AccessArticle

Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke

1
Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, 24253 Chuncheon, Korea
2
Department of Endocrinology and Metabolism, Kyung Hee University Hospital, 02247 Seoul, Korea
3
Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 18450 Hwaseong, Korea
4
Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 05355 Seoul, Korea
5
Departement of Emergency Medicine, Graduate School, Kyung Hee University, 02453 Seoul, Korea
*
Author to whom correspondence should be addressed.
These authors were equally contributed to work.
Medicina 2020, 56(6), 307; https://doi.org/10.3390/medicina56060307
Received: 25 May 2020 / Revised: 8 June 2020 / Accepted: 19 June 2020 / Published: 23 June 2020
Background and objectives: Little is known about the effect of osteoporosis on cognitive function in the acute and recovery phases of stroke. Early bone mineral density assessments during acute stroke may be a useful marker of cognitive function. We evaluated the effect of osteoporosis on cognitive function at the early and recovery phase of ischemic stroke in patients aged >50 years. Materials and Methods: We retrospectively examined consecutive patients with acute stroke hospitalized between 2016 and 2018. Osteoporosis was defined as a T-score <–2.5 for the femoral neck or lumbar spine bone mineral density. The primary outcome was cognitive impairment measured by the Korean Mini-Mental State Examination in the acute phase and recovery phase of ischemic stroke. Results: Of the 260 included subjects (107 men and 153 women), 70 (26.9%) had osteoporosis. Cognitive impairment was more severe in the osteoporosis group than in the non-osteoporosis group (30.5% versus 47.1%, p = 0.001). After the recovery phase of stroke, the proportion of patients with cognitive impairment remained higher in the osteoporosis group. The multivariate analysis revealed a correlation between a low femoral neck bone mineral density and severe cognitive impairment in the acute and recovery phases of stroke (adjusted odds ratio (OR) 4.09, 95% confidence interval (CI) 1.11–15.14 in the acute phase, and adjusted OR 11.17, 95% CI 1.12–110.98 in the recovery phase). Conclusions: Low bone mineral density is associated with poor cognitive function in the acute and recovery phases of stroke. View Full-Text
Keywords: osteoporosis; bone mineral density; cognitive impairment; white matter disease; ischemic stroke osteoporosis; bone mineral density; cognitive impairment; white matter disease; ischemic stroke
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Lee, S.-H.; Park, S.Y.; Jang, M.U.; Kim, Y.; Lee, J.; Kim, C.; Kim, Y.J.; Sohn, J.-H. Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke. Medicina 2020, 56, 307.

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