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Open AccessArticle

Tumor Suppressors—HTRA Proteases and Interleukin-12—in Pediatric Asthma and Allergic Rhinitis Patients

Department of General and Medical Biochemistry, University of Gdańsk, Wita Stwosza 59 80-308 Gdańsk, Poland
Department of Allergology, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland
Department of Immunobiology and Environmental Microbiology Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland
Department of Bacterial Molecular Genetics University of Gdańsk Wita Stwosza 59, 80-308 Gdańsk, Poland
Faculty of Health Sciences with Subfaculty of Nursing, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland
Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Hallera 107, 80-416 Gdańsk, Poland
Laboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-512 Poznan, Poland
Department of Occupational, Metabolic and Internal Diseases, Medical University of Gdańsk, Powstania Styczniowego 9B, 81-519 Gdynia, Poland
Author to whom correspondence should be addressed.
Medicina 2020, 56(6), 298;
Received: 12 May 2020 / Revised: 12 June 2020 / Accepted: 12 June 2020 / Published: 17 June 2020
(This article belongs to the Special Issue Pediatric Allergy and Immunology)
Background and objective: Allergy belongs to a group of mast cell-related disorders and is one of the most common diseases of childhood. It was shown that asthma and allergic rhinitis diminish the risk of various cancers, including colon cancer and acute lymphoblastic leukemia. On the other hand, asthma augments the risk of lung cancer and an increased risk of breast cancer in patients with allergy has been observed. Thus, the relation between allergy and cancer is not straightforward and furthermore, its biological mechanism is unknown. The HTRA (high temperature requirement A) proteases promote apoptosis, may function as tumor suppressors and HTRA1 is known to be released by mast cells. Interleukin-12 (Il-12) is an important cytokine that induces antitumor immune responses and is produced mainly by dendritic cells that co-localize with mast cells in superficial organs. Material and methods: In the present study we have assessed with ELISA plasma levels of the HTRA proteins, Il-12, and of the anti-HTRA autoantibodies in children with allergy (40) and in age matched controls (39). Children are a special population, since they usually do not have comorbidities and take not many drugs the processes we want to observe are not influenced by many other factors. Results: We have found a significant increase of HTRA1, 2 and 3, and of the Il-12 levels in the children with atopy (asthma and allergic rhinitis) compared to controls. Conclusion: Our results suggest that the HTRA1–3 and Il-12 levels might be useful in analyzing the pro- and antioncogenic potential in young atopic patients. View Full-Text
Keywords: HTRA proteases; Il-12; allergy; oncogenesis; mast cells HTRA proteases; Il-12; allergy; oncogenesis; mast cells
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Renke, J.; Wasilewska, E.; Kędzierska-Mieszkowska, S.; Zorena, K.; Barańska, S.; Wenta, T.; Liberek, A.; Siluk, D.; Żurawa-Janicka, D.; Szczepankiewicz, A.; Renke, M.; Lipińska, B. Tumor Suppressors—HTRA Proteases and Interleukin-12—in Pediatric Asthma and Allergic Rhinitis Patients. Medicina 2020, 56, 298.

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