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Gastrointestinal Symptoms of and Psychosocial Changes in Inflammatory Bowel Disease: A Nursing-Led Cross-Sectional Study of Patients in Clinical Remission
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Incidence of Prostate Cancer in Inflammatory Bowel Disease: A Meta-Analysis

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Unit of Gastroenterology, Department of Medical Sciences, University of Turin, 10126 Turin, Italy
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Department of Medical Sciences, University of Turin, 10126 Turin, Italy
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Unit of Gastroenterology, Molinette Hospital, 10126 Turin, Italy
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Institute of Biostructure and Bioimaging, CNR c/o Molecular Biotechnology Centre, 10126 Turin, Italy
*
Author to whom correspondence should be addressed.
Medicina 2020, 56(6), 285; https://doi.org/10.3390/medicina56060285
Received: 18 May 2020 / Revised: 4 June 2020 / Accepted: 5 June 2020 / Published: 11 June 2020
Background and objectives: Inflammatory bowel disease (IBD) is associated with an increased risk of developing colorectal cancer as well as some extra-intestinal tumors, but there are still limited data about the risk of prostate cancer (PC). To analyze if there is an increased risk of PC in patients affected by IBD, we performed a systematic review with meta-analysis. Materials and Methods: A Pubmed search of all studies comparing standardized incidence ratio (SIR) or odds ratio (OR) or relative risks (RR) of PC between IBD and non IBD groups, published until March 2020 was conducted. The study protocol was registered on PROSPERO. Twelve studies, mostly population studies, were included. The quality score of these studies, evaluated by the Newcastle–Ottawa Scale, was 7. The heterogeneity was high among the studies in which ulcerative colitis (UC) was considered separate from Crohn’s disease (CD) and in the studies that considered UC and CD together (“IBD-studies”), while it was low in the studies which considered CD separate from UC. Results: The relative risk of developing PC was 1.71 (95% confidence interval [CI] 1.16–2.51, p = 0.007) in IBD, 1.10 (95%CI 0.98–1.25, p = 0.116) in CD, and 1.22 (95%CI 0.98–1.51, p = 0.07) in UC. Conclusions: Patients with IBD appear to have a slightly increased risk of PC compared to the general population. View Full-Text
Keywords: Crohn’s disease; ulcerative colitis; urological cancer; screening; systematic review Crohn’s disease; ulcerative colitis; urological cancer; screening; systematic review
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Carli, E.; Caviglia, G.P.; Pellicano, R.; Fagoonee, S.; Rizza, S.; Astegiano, M.; Saracco, G.M.; Ribaldone, D.G. Incidence of Prostate Cancer in Inflammatory Bowel Disease: A Meta-Analysis. Medicina 2020, 56, 285.

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