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Open AccessArticle

Inherited Risk Factors of Thromboembolic Events in Patients with Primary Nephrotic Syndrome

1
Department of Nephrology, Fundeni Clinical Institute, Bucharest 022328, Romania
2
Department of Uronephrology, “Carol Davila” University of Medicine and Pharmacy, Bucharest 020021, Romania
3
Center of Uronephrology and Renal Transplantation, Fundeni Clinical Institute, Bucharest 022328, Romania
*
Author to whom correspondence should be addressed.
Medicina 2020, 56(5), 242; https://doi.org/10.3390/medicina56050242
Received: 23 April 2020 / Revised: 10 May 2020 / Accepted: 16 May 2020 / Published: 19 May 2020
(This article belongs to the Special Issue Interdisciplinary Medicine)
Background and objectives. Venous thromboembolic events (VTEs) are among the most important complications of nephrotic syndrome (NS). We conducted a study that aimed to determine the prevalence of inherited risk factors for VTE in NS and to identify which factors are independent predictors of VTE. Materials and Methods. Thirty-six consecutive patients with primary NS that underwent percutaneous kidney biopsy between January 2017 and December 2017 were enrolled in this retrospective, observational study. VTEs were the primary outcome. Baseline demographic and biochemical data were collected from medical records, and genetic testing was done for polymorphisms of Factor V, PAI, MTHFR, and prothrombin genes. Results. The incidence of VTE was 28%, and the median time to event was 3 months (IQR: 2–9). The prevalence of inherited risk factors was 14% for Factor V Leiden mutation, 5.6% for prothrombin G20210A, 44.5% for PAI, and 27.8% for each of the two polymorphisms of the MTHFR gene. On multivariate analysis, the presence of at least two mutations was independently associated with the risk of VTE (HR, 8.92; 95% confidence interval, CI: 1.001 to 79.58, p = 0,05). Conclusions. These findings suggest that genetic testing for inherited thrombophilia in NS could play an important role in detecting high-risk patients that warrant prophylactic anticoagulation. View Full-Text
Keywords: nephrotic syndrome; thrombosis; inherited risk factors; mutation; anticoagulation nephrotic syndrome; thrombosis; inherited risk factors; mutation; anticoagulation
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Ismail, G.; Obrișcă, B.; Jurubiță, R.; Andronesi, A.; Sorohan, B.; Hârza, M. Inherited Risk Factors of Thromboembolic Events in Patients with Primary Nephrotic Syndrome. Medicina 2020, 56, 242.

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