Next Article in Journal
Sepsis Associated Delirium
Previous Article in Journal
Determination of Referential Rates for Optical Coherence Tomography and Optical Coherence Tomography Angiography Flow Deficits in the Macular Choriocapillaris in Ophthalmologically Healthy Children
Open AccessArticle

Clinical Characteristics of Mitochondrial DNA Copy Number in Osteonecrosis of the Femoral Head

1
Department of Orthopaedic Surgery, Keimyung University School of Medicine, Dongsan Hospital, Daegu 42601, Korea
2
Department of Anatomy, School of Medicine, Keimyung University, Daegu 42601, Korea
*
Author to whom correspondence should be addressed.
Medicina 2020, 56(5), 239; https://doi.org/10.3390/medicina56050239
Received: 6 April 2020 / Revised: 2 May 2020 / Accepted: 13 May 2020 / Published: 16 May 2020
(This article belongs to the Section Translational Medicine)
Background and objectives: Alterations in mitochondrial DNA (mtDNA) have been observed and studied in various diseases. However, the clinical value of the mtDNA copy number (mtDNA-CN) alterations in osteonecrosis of the femoral head (ONFH) is poorly understood. In the present study, we investigated whether alterations in mtDNA-CNs are associated with clinicopathological parameters in ONFH. Materials and methods: MtDNA-CNs in the synovial tissue of 34 patients with ONFH and 123 control tissues (femoral neck fracture) were measured using quantitative real-time PCR. The present study then analyzed the correlation between the mtDNA-CN and the clinicopathological characteristics of ONFH and fracture patients. Results: The average mtDNA-CN (mean ± standard deviation) was 23.82 ± 22.37 and 25.04 ± 24.27 in ONFH and control tissues, respectively, and was not significantly different between the groups (p = 0.792). The mtDNA-CN was positively associated with age (27.7% vs. 45.9%, p = 0.018) and negatively associated with the erythrocyte sedimentation rate (ESR) (11.8% vs. 39.7%, p = 0.024) in all of the samples. The study also found further associations with age (22.2% vs. 68.8%, p = 0.014), gender (30.0% vs. 64.3%, p = 0.048), and ESR (0% vs. 57.7%, p = 0.043) in ONFH. Conclusions: in this study, we demonstrated that mtDNA-CN might be a significant marker for predicting clinical characteristics in ONFH. View Full-Text
Keywords: mtDNA; mtDNA-CN; ONFH; osteonecrosis; mitochondrial DNA; ESR; mtDNA copy number mtDNA; mtDNA-CN; ONFH; osteonecrosis; mitochondrial DNA; ESR; mtDNA copy number
Show Figures

Figure 1

MDPI and ACS Style

Lee, S.-W.; Lee, K.-J.; Kim, B.-S.; Kwon, H.-J.; Lee, J.-H. Clinical Characteristics of Mitochondrial DNA Copy Number in Osteonecrosis of the Femoral Head. Medicina 2020, 56, 239.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop