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Open AccessArticle

Could FeNO Predict Asthma in Patients with House Dust Mites Allergic Rhinitis?

1
Department of Allergology and Immunology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400162 Cluj Napoca, Romania
2
Toxicology and Clinical Pharmacology, Department of Pharmacology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400337 Cluj Napoca, Romania
3
Department of Clinical Immunology, Sahlgrenska University Hospital, 41346 Göteborg, Sweden
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Medicina 2020, 56(5), 235; https://doi.org/10.3390/medicina56050235
Received: 13 April 2020 / Revised: 30 April 2020 / Accepted: 11 May 2020 / Published: 14 May 2020
Background and Objectives: The evolution of allergic rhinitis to asthma is a part of “atopic march”. The aim of this study was to analyze possible predictive markers for asthma occurrence in patients with allergic rhinitis to house dust mites (HDM). Materials and Methods: Fifty-eight patients with persistent allergic rhinitis (PAR) were included. The clinical, biological evaluation and fractionated exhaled nitric oxide (FeNO) measurement were performed at enrolment. The patients were clinically evaluated after one year to determine asthma occurrence. Results: The severity of rhinitis symptoms, levels of total immunoglobulin E (IgE), ICAM-1, VCAM-1, E-selectin and IL-6, but not IL-8 and TNF-α were higher in patients with allergic rhinitis who developed asthma compared to non-asthmatics, but the differences were not significant to considered them as predictive factors for asthma occurrence. The risk of asthma was independently influenced by patients aged over 30 years ((OR-3.74; CI95% 0.86–16.31; p = 0.07), a duration of allergic rhinitis over 12 months ((OR-4.20; CI95% 0.88–20; p = 0.07) and a basal FeNO over 28 parts per billion (pbb) ((OR-18.68; CI95% 3.79–92.05; p < 0.001). Conclusion: Clinical and biological parameters may predict asthma occurrence in patients with persistent allergic rhinitis to HDM. Adult patients with a longer duration of rhinitis symptoms and a high level of FeNO have a greater risk to develop asthma. View Full-Text
Keywords: allergic rhinitis; allergic inflammation; asthma; FeNO; house dust mites allergic rhinitis; allergic inflammation; asthma; FeNO; house dust mites
MDPI and ACS Style

Muntean, I.A.; Bocsan, I.C.; Vesa, S.; Miron, N.; Nedelea, I.; Buzoianu, A.D.; Deleanu, D. Could FeNO Predict Asthma in Patients with House Dust Mites Allergic Rhinitis? Medicina 2020, 56, 235.

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