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Open AccessArticle

The Relationship Between Contrast Associated Nephropathy and Coronary Collateral Circulation in very Old Patients

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Cardiology Department, Balikesir University Faculty of Medicine, 10100 Balikesir, Turkey
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Department of Cardiology, University of Health Sciences Turkey, Kartal Kosuyolu High Specialty Educational and Research Hospital, 34865, Istanbul, Turkey
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Department of Cardiovascular Surgery, Balikesir University Faculty of Medicine, 10100 Balikesir, Turkey
*
Author to whom correspondence should be addressed.
Medicina 2020, 56(3), 99; https://doi.org/10.3390/medicina56030099
Received: 9 January 2020 / Revised: 12 February 2020 / Accepted: 23 February 2020 / Published: 27 February 2020
(This article belongs to the Special Issue Markers of Inflammation in Atherosclerosis)
Background: The aim of this study was to investigate whether there is a relationship between coronary collateral circulation (CCC) and contrast associated nephropathy (CAN) in very elderly patients. Methods: Patients aged 90 years or older with at least one major occlusion of the coronary artery proximal or mid-section were included in the study. CCC was graded according to the Rentrop classification. CAN was defined as an increase in blood creatinine value of 25% or more on the second day after coronary angiography. Results: Thirty-six patients who met the study criteria were included in the study. In the study group, CAN developed in 12 patients (CAN (+) group), 24 patients did not develop CAN (CAN (−) group). The creatinine levels before coronary angiography were 1.05 ± 0.12 in the CAN (−) group and 1.22 ± 0.14 in the CAN (+) group. Baseline creatinine values were significantly higher in the CAN (+) group (p = 0.001). The contrast agent used in the CAN (+) group was significantly higher (p = 0.001). In the CAN (+) group, nine patients (43%) had poor collateral circulation, whereas only three patients (20%) had well-developed collateral circulation. In a logistic regression analysis, the collateral class was not a risk factor for CAN, whereas contrast agent volume and basal creatinine were independent predictors of CAN. Conclusion: We found that CCC grade was not associated with the development of CAN in very old patients, but the amount of contrast agent and pre-procedure creatinine values were independent variables in the development of CAN. View Full-Text
Keywords: Contrast associated nephropathy; Coronary collateral circulation; Endothelial function; Very old patient Contrast associated nephropathy; Coronary collateral circulation; Endothelial function; Very old patient
MDPI and ACS Style

Yildirim, T.; Ozkan, B.; Alici, G.; Yildirim, S.E.; Bugra, O.; Kadi, H. The Relationship Between Contrast Associated Nephropathy and Coronary Collateral Circulation in very Old Patients. Medicina 2020, 56, 99.

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