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Ultra-Early and Early Changes in Bile Acids and Insulin after Sleeve Gastrectomy among Obese Patients
Open AccessArticle

Role of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional Study

1
Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, UAE
2
Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, UAE
3
Ambulatory Medicine (Dep) - Medical Affairs, Tawam Hospital (S.A.M.), Al Ain 17666, UAE
4
Department of Pharmacology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, UAE
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Medicina 2020, 56(3), 142; https://doi.org/10.3390/medicina56030142
Received: 7 January 2020 / Revised: 20 February 2020 / Accepted: 24 February 2020 / Published: 20 March 2020
Background and objectives: Although laparoscopic sleeve gastrectomy (LSG) is effective for obesity management, postoperative vitamin B12 (B12) deficiency is of major concern. In this cross-sectional study, we assessed the levels of B12 and its related functional biomarkers, namely, total homocysteine (tHcy), methylmalonic acid (MMA), folate, methylcitric acid (MCA), and hemoglobin (Hb), in one-year postoperative LSG patients and matched controls. Materials and Methods: Plasma B12, tHcy, MMA, folate, and MCA were measured in matched controls (n = 66) and patients (n = 71) using validated liquid chromatography-tandem mass spectrometry techniques and protocols in the United Arab Emirates (UAE). Results: The median B12 concentration in patients (177 pmol/L) was significantly lower (p < 0.001) than in the controls (334.7 pmol/L). The tHcy and MMA levels were significantly increased (p < 0.001 and p = 0.011, respectively) and folate levels were significantly decreased (p = 0.001) in the LSG patients compared to the controls. Interestingly, no significant difference in MCA levels were observed between the two groups. The levels of tHcy and MMA were concomitantly increased with the decreased folate levels in postoperative LSG patients when compared with the controls. The Hb levels were significantly lower in males and females in the patient group compared with those in the control group, respectively (p = 0.005 and p = 0.043). Conclusions: This is the first report of serum levels of B12 and its functional biomarkers in postoperative LSG patients among a local population from the UAE. Our findings revealed significant alterations of the B12 biomarkers, total B12, MMA, and tHcy in one-year postoperative LSG patients. View Full-Text
Keywords: bariatric surgery; homocysteine; methylmalonic acid; methylcitric acid; vitamin B12; UAE bariatric surgery; homocysteine; methylmalonic acid; methylcitric acid; vitamin B12; UAE
MDPI and ACS Style

Al-Dirbashi, O.Y.; Sharma, C.; Al Dahouri, N.; Al Aidaros, A.; Al-Muhairi, S.; Beiram, R.; Gariballa, S.; Al Kaabi, J. Role of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional Study. Medicina 2020, 56, 142.

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