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Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care?

1
Department of Gastroenterology, 401 Army General Hospital of Athens, 11525 Athens, Greece
2
Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, 54642 Thessaloniki, Greece
3
Department of Gastroenterology, Army Share Fund Hospital (NIMTS), 11521 Athens, Greece
4
Department of Gastroenterology, Athens Medical, Paleo Faliron Hospital, 17562 Palaio Faliro, Greece
5
Gastroenterology & Liver Unit, National and Kapodistrian University of Athens, General & Oncology Hospital of Kifissia “Agioi Anargyroi”, 14564 Kifissia, Greece
6
Department of Emergency Medicine, University Hospital Inselspital Bern, 3010 Bern, Switzerland
7
Gastroenterological Clinic, Henry Dunant Hospital, 11526 Athens, Greece
8
Department of Gastroenterology and Hepatology, University of Zurich, 8091 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Medicina 2020, 56(3), 133; https://doi.org/10.3390/medicina56030133
Received: 20 January 2020 / Revised: 9 March 2020 / Accepted: 10 March 2020 / Published: 18 March 2020
Helicobacter pylori (Hp) management has undoubtedly resulted in a notable economic burden on healthcare systems globally, including Greece. Its cost has never been estimated so far, especially during the recent 10-year unprecedented financial crisis. Direct medical and procedural costs for one attempt “outpatient” Hp eradication treatment were estimated as the following: (I) first-line regimens: 10 and 14 days standard triple, 10 and 14 days sequential, 10 and 14 days concomitant non-bismuth quadruple, 14 days hybrid, (II) second-line salvage regimens: 10 and 14 days levofloxacin-containing triple regimens. Treatment costs using prototypes and/or generic drugs were calculated. Drug prices were collected and confirmed from two official online medical databases including all medicines approved by the Greek National Organization for Medicines. Regimens based on generics were more affordable than prototypes and those including pantoprazole yielded the lowest prices (mean: 27.84 €). Paradoxically, 10-day concomitant and 14-day hybrid regimens (currently providing good (90–94%) first-line eradication rates in Greece) cost the same (mean: 34.76 €). The expenditures for Hp eradication treatment regimens were estimated thoroughly for the first time in Greece. These data should be taken into account by Public Health policymakers both in Greece and the European Union, aiming for a better and less expensive therapeutic approach. View Full-Text
Keywords: Helicobacter pylori; Hp infection; treatment cost; eradication regimens Helicobacter pylori; Hp infection; treatment cost; eradication regimens
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Liatsos, C.; Papaefthymiou, A.; Kyriakos, N.; Giakoumis, M.; Kountouras, J.; Galanopoulos, M.; Apostolopoulos, P.; Georgopoulos, S.D.; Mavrogiannis, C.; Exadaktylos, A.K.; Srivastava, D.S.; Rokkas, T.; Doulberis, M. Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care? Medicina 2020, 56, 133.

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