Next Article in Journal
Midpalatal Suture Density Evaluation after Rapid and Slow Maxillary Expansion with a Low-Dose CT Protocol: A Retrospective Study
Previous Article in Journal
Ischemic Etiology and Clinical Outcomes Following Cardiac Resynchronization Therapy
Open AccessReview

Immunoglobulin E (IgE)-Mediated Food Allergy in Children: Epidemiology, Pathogenesis, Diagnosis, Prevention, and Management

Allergy Unit, Department of Pediatrics, Meyer Children’s University Hospital, 50139 Florence, Italy
*
Author to whom correspondence should be addressed.
Medicina 2020, 56(3), 111; https://doi.org/10.3390/medicina56030111
Received: 28 January 2020 / Revised: 25 February 2020 / Accepted: 28 February 2020 / Published: 4 March 2020
A food allergy is an immunoglobulin E (IgE)-mediated hypersensitive reaction to food, which consists in the appearance of allergic symptoms; it can vary from common urticaria to even fatal anaphylaxis. The prevalence of food allergies has been increasing in the past twenty years and it represents a major public health problem in industrialized countries. The mechanism that leads to food allergies is the lack of immunologic and clinical tolerance to food allergens. The diagnosis of IgE-mediated food allergies is based on the combined use of a detailed medical history, in-vivo, and in-vitro research of specific IgE, the elimination diet, and the double-blind placebo-controlled food challenge. The only currently available treatment for allergies is the strict elimination diet. This type of attitude, which we could define as “passive”, does not overcome the risk of accidental reactions due to involuntary intake of the culprit food. For food allergy management, an “active” approach is urgently needed, such as specific allergen immunotherapy, which is currently under development and only used for research purposes. This article aims to give an updated review of IgE-mediated food allergies in pediatric populations in terms of epidemiology, pathogenesis, prevention, diagnosis, and management. View Full-Text
Keywords: children; diagnosis; epidemiology; food allergy management; pathogenesis; prevention children; diagnosis; epidemiology; food allergy management; pathogenesis; prevention
Show Figures

Figure 1

MDPI and ACS Style

Barni, S.; Liccioli, G.; Sarti, L.; Giovannini, M.; Novembre, E.; Mori, F. Immunoglobulin E (IgE)-Mediated Food Allergy in Children: Epidemiology, Pathogenesis, Diagnosis, Prevention, and Management. Medicina 2020, 56, 111.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop