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Open AccessArticle

The Risk of Para-Aortic Lymph Node Metastases in Apparent Early Stage Ovarian Cancer

1
“Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
2
Department of Obstetrics and Gynecology, “I. Cantacuzino” Clinical Hospital, 030167 Bucharest, Romania
3
Department of Visceral Surgery, Center of Excellence in Translational Medicine, “Fundeni” Clinical Institute, 022328 Bucharest, Romania
4
Department of Surgery, “Ponderas” Academic Hospital, 021188 Bucharest, Romania
5
Department of Visceral Surgery, “I. Cantacuzino” Clinical Hospital, 030167 Bucharest, Romania
6
Department of Internal Medicine, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania
7
Department of Internal Medicine, “Fundeni” Clinical Institute, 022328 Bucharest, Romania
8
Department of Obstetrics and Gynecology, “Elias” Emergency University Hospital, 011461 Bucharest, Romania
9
Department of Obstetrics and Gynecology, “St Pantelimon” Emergency Hospital, 021661 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Authors with equal contribution.
Medicina 2020, 56(3), 108; https://doi.org/10.3390/medicina56030108
Received: 19 January 2020 / Revised: 13 February 2020 / Accepted: 21 February 2020 / Published: 3 March 2020
(This article belongs to the Special Issue Interdisciplinary Medicine)
Background and objectives: To identify the risk factors for para-aortic lymph node metastases in cases with presumed early stage ovarian cancer. Materials and methods: Between 2014 and 2019, 48 patients with apparent early stage ovarian cancer were submitted to surgery. In all cases, pelvic and para-aortic lymph node dissection was performed for staging purposes. Results: Among the 48 cases we identified nine cases with positive pelvic lymph nodes and 11 cases with positive para-aortic lymph nodes. The positivity of the retrieved lymph nodes was significantly correlated with the histopathological subtype represented by serous histology (p = 0.02), as well as with the degree of differentiation (p = 0.004). Conclusions: Patients with serous ovarian carcinomas in association with a poorer degree of differentiation are at risk of associated lymph node metastases even in presumed early stages of the disease. Therefore, lymph node dissection should be performed in such cases in order to provide adequate staging and tailoring of further treatment. View Full-Text
Keywords: early stage; ovarian cancer; para-aortic lymph node metastases early stage; ovarian cancer; para-aortic lymph node metastases
MDPI and ACS Style

Bacalbasa, N.; Balescu, I.; Vilcu, M.; Dima, S.; Diaconu, C.; Iliescu, L.; Filipescu, A.; Dimitriu, M.; Brezean, I. The Risk of Para-Aortic Lymph Node Metastases in Apparent Early Stage Ovarian Cancer. Medicina 2020, 56, 108.

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