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Open AccessArticle

Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture’s Syndrome in the United States: Nationwide Inpatient Sample 2003–2014

1
Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
2
Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok 10400, Thailand
3
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
4
Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
5
Department of Internal Medicine, University of Arizona, Tucson, AZ 85721, USA
6
Department of Internal Medicine, St. Agnes Hospital, Baltimore, MD 21229, USA
7
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA
8
Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
*
Author to whom correspondence should be addressed.
Medicina 2020, 56(3), 103; https://doi.org/10.3390/medicina56030103
Received: 4 February 2020 / Revised: 20 February 2020 / Accepted: 25 February 2020 / Published: 1 March 2020
Background and objectives: Goodpasture’s syndrome (GS) is a rare, life-threatening autoimmune disease. Although the coexistence of anti-neutrophil cytoplasmic antibody (ANCA) with Goodpasture’s syndrome has been recognized, the impacts of ANCA vasculitis on mortality and resource utilization among patients with GS are unclear. Materials and Methods: We used the National Inpatient Sample to identify hospitalized patients with a principal diagnosis of GS from 2003 to 2014 in the database. The predictor of interest was the presence of ANCA-associated vasculitis. We tested the differences concerning in-hospital treatment and outcomes between GS patients with and without ANCA-associated vasculitis using logistic regression analysis with adjustment for other clinical characteristics. Results: A total of 964 patients were primarily admitted to hospital for GS. Of these, 84 (8.7%) had a concurrent diagnosis of ANCA-associated vasculitis. Hemoptysis was more prevalent in GS patients with ANCA-associated vasculitis. During hospitalization, GS patients with ANCA-associated required non-significantly more mechanical ventilation and non-invasive ventilation support, but non-significantly less renal replacement therapy and plasmapheresis than those with GS alone. There was no significant difference in in-hospital outcomes, including organ failure and mortality, between GS patients with and without ANCA-associated vasculitis. Conclusions: Our study demonstrated no significant differences between resource utilization and in-hospital mortality among hospitalized patients with coexistence of ANCA vasculitis and GS, compared to those with GS alone. View Full-Text
Keywords: Goodpasture syndrome; ANCA; anti-GBM disease; vasculitis; hospitalization; outcomes Goodpasture syndrome; ANCA; anti-GBM disease; vasculitis; hospitalization; outcomes
MDPI and ACS Style

Thongprayoon, C.; Kaewput, W.; Boonpheng, B.; Ungprasert, P.; Bathini, T.; Srivali, N.; Vallabhajosyula, S.; Castaneda, J.L.; Monga, D.; Kanduri, S.R.; Medaura, J.; Cheungpasitporn, W. Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture’s Syndrome in the United States: Nationwide Inpatient Sample 2003–2014. Medicina 2020, 56, 103.

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