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MiRNA-Based Inspired Approach in Diagnosis of Prostate Cancer

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Department of Urology, The Oncology Institute “Prof Dr. Ion Chiricuta”, 400015 Cluj-Napoca, Romania
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Department of Urology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
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Medfuture- Research Center for Advanced Medicine “Iuliu Hatieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
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Research Center for Functional Genomics, Biomedicine and Translational Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
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Department of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta”, 400015 Cluj-Napoca, Romania
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Department of Urology, Clinical Municipal Hospital, 400139 Cluj-Napoca, Romania
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Authors to whom correspondence should be addressed.
Medicina 2020, 56(2), 94; https://doi.org/10.3390/medicina56020094
Received: 13 December 2019 / Revised: 10 February 2020 / Accepted: 19 February 2020 / Published: 24 February 2020
Prostate cancer is one of the most encountered cancer diseases in men worldwide and in consequence it requires the improvement of therapeutic strategies. For the clinical diagnosis, the standard approach is represented by solid biopsy. From a surgical point of view, this technique represents an invasive procedure that may imply several postoperative complications. To overcome these impediments, many trends are focusing on developing liquid biopsy assays and on implementing them in clinical practice. Liquid samples (blood, urine) are rich in analytes, especially in transcriptomic information provided by genetic markers. Additionally, molecular characterization regarding microRNAs content reveals outstanding prospects in understanding cancer progression mechanisms. Moreover, these analytes have great potential for prostate cancer early detection, more accurate prostate cancer staging and also for decision making respecting therapy schemes. However, there are still questionable topics and more research is needed to standardize liquid biopsy-based techniques. View Full-Text
Keywords: prostate cancer; biofluids; liquid biopsy; microRNAs; Gleason score prostate cancer; biofluids; liquid biopsy; microRNAs; Gleason score
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Munteanu, V.C.; Munteanu, R.A.; Onaciu, A.; Berindan-Neagoe, I.; Petrut, B.; Coman, I. MiRNA-Based Inspired Approach in Diagnosis of Prostate Cancer. Medicina 2020, 56, 94.

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