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Open AccessCase Report

Rare Breast Carcinoma with Paradoxical Plasma Cell Immunoprofile: A Case Report

IV Surgical Department, University Emergency Hospital, 050098 Bucharest, Romania
Department of Surgery, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
Department of Pathology, Regina Maria Central Laboratory, 060044 Bucharest, Romania
Department of Pathology, County Emergency Hospital, 900591 Constanța, Romania
Faculty of Materials Science and Engineering, Politehnica University of Bucharest, 060042 Bucharest, Romania
Author to whom correspondence should be addressed.
Medicina 2020, 56(2), 62;
Received: 4 December 2019 / Revised: 17 January 2020 / Accepted: 29 January 2020 / Published: 5 February 2020
Plasma cell features are encountered in a variety of non-plasma cell neoplasias, especially carcinomas of a discohesive type, such as those occurring in the digestive tract and breast. Lobular carcinomas of the breast present themselves in a variety of architectural patterns and many cell morphologies, including plasmacytoid types. A matching plasma cell phenotype is sometimes an associated feature. We report a case of a moderate grade invasive lobular carcinoma with focal plasmacytoid morphology and aberrant expression of plasma cell markers in a patient previously diagnosed with multiple myeloma. Paradoxical plasma cell immunoprofiles can be encountered in many malignancies, causing serious diagnostic problems, even more so with those occurring in discohesive carcinomas in multiple myeloma patients.
Keywords: lobular carcinoma; plasma cell differentiation; multiple myeloma lobular carcinoma; plasma cell differentiation; multiple myeloma
MDPI and ACS Style

Grădinaru, E.S.; Stoicea, M.-C.; Mocanu, L.; Antoniac, I.; Gheorghiță, D.; Grigore, A.G.M. Rare Breast Carcinoma with Paradoxical Plasma Cell Immunoprofile: A Case Report. Medicina 2020, 56, 62.

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