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Open AccessArticle

Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study

by Yi-Ju Lee 1,2, Lung Chan 3, Chung-Min Yeh 4,5, Chien-Hsun Lee 4,*,† and Wen-Wei Sung 3,6,7,*,†
1
Department of Pathology, Chung Shan Medical University, Taichung 40201, Taiwan
2
Department of Pathology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
3
School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
4
Department of Pathology, Changhua Christian Hospital, Changhua 50006, Taiwan
5
Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 35664, Taiwan
6
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
7
Department of Urology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Medicina 2020, 56(2), 57; https://doi.org/10.3390/medicina56020057
Received: 21 December 2019 / Revised: 17 January 2020 / Accepted: 27 January 2020 / Published: 30 January 2020
Background and Objectives: Patients with oral squamous cell carcinoma (OSCC), a common malignancy in Asian countries, have a poor prognosis. We investigated the role of Krüppel-like factor 17 (KLF17) and its prognostic significance in OSCC. Materials and Methods: KLF17 expression was measured by immunohistochemical staining of specimens from 283 patients with OSCC. We analyzed correlations between KLF17 expression and clinicopathologic features and between KLF17 expression and overall survival. The prognostic value of KLF17 was tested using Kaplan–Meier analysis and Cox proportional hazard models. Results: Among the 283 patients, high KLF17 expression was significantly associated with an early OSCC stage and low T-value (p = 0.033 and p = 0.036, respectively). The five-year survival rates were better in patients with high KLF17 expression than with low expression (66.5% and 49.6%, respectively). The prognostic role of KLF17 was further confirmed through multivariate analysis (hazard ratio 1.506, 95% confidence interval 1.034–2.191, p = 0.033). The prognostic value was more significant in patients with a history of betel quid chewing or with a low T-value. Conclusions: High KLF17 expression can serve as a marker for a favorable prognosis in patients with OSCC. The prognostic role of KLF17 is more significant in patients with a history of betel quid chewing or a low T-value.
Keywords: Krüppel-like factor 17; KLF17; prognosis; oral cancer; oral squamous cell carcinoma; overall survival Krüppel-like factor 17; KLF17; prognosis; oral cancer; oral squamous cell carcinoma; overall survival
MDPI and ACS Style

Lee, Y.-J.; Chan, L.; Yeh, C.-M.; Lee, C.-H.; Sung, W.-W. Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study. Medicina 2020, 56, 57.

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