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Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis

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Orthodontics Teaching Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain
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Preventive Dentistry Teaching Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain
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GROC·UJI, Institute of New Imaging Technologies, Universitat Jaume I, 12071 Castellón, Spain
*
Author to whom correspondence should be addressed.
Medicina 2020, 56(2), 55; https://doi.org/10.3390/medicina56020055
Received: 11 November 2019 / Revised: 22 January 2020 / Accepted: 22 January 2020 / Published: 29 January 2020
(This article belongs to the Section Dentistry)
Background and Objectives: Nanotechnology has become a significant area of research focused mainly on increasing the antibacterial and mechanical properties of dental materials. The aim of the present systematic review and meta-analysis was to examine and quantitatively analyze the current evidence for the addition of different nanoparticles into dental restorative materials, to determine whether their incorporation increases the antibacterial/antimicrobial properties of the materials. Materials and Methods: A literature search was performed in the Pubmed, Scopus, and Embase databases, up to December 2018, following PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines for systematic reviews and meta-analyses. Results: A total of 624 papers were identified in the initial search. After screening the texts and applying inclusion criteria, only 11 of these were selected for quantitative analysis. The incorporation of nanoparticles led to a significant increase (p-value < 0.01) in the antibacterial capacity of all the dental materials synthesized in comparison with control materials. Conclusions: The incorporation of nanoparticles into dental restorative materials was a favorable option; the antibacterial activity of nanoparticle-modified dental materials was significantly higher compared with the original unmodified materials, TiO2 nanoparticles providing the greatest benefits. However, the high heterogeneity among the articles reviewed points to the need for further research and the application of standardized research protocols. View Full-Text
Keywords: nanoparticles; nanotechnology; orthodontic adhesive; dental bonding materials; antibacterial nanoparticles; nanotechnology; orthodontic adhesive; dental bonding materials; antibacterial
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Ferrando-Magraner, E.; Bellot-Arcís, C.; Paredes-Gallardo, V.; Almerich-Silla, J.M.; García-Sanz, V.; Fernández-Alonso, M.; Montiel-Company, J.M. Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis. Medicina 2020, 56, 55.

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