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Open AccessArticle

Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer

Department of Anatomy, Keimyung University School of Medicine, Daegu 42061, Korea
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Medicina 2020, 56(2), 48; https://doi.org/10.3390/medicina56020048 (registering DOI)
Received: 11 December 2019 / Revised: 14 January 2020 / Accepted: 19 January 2020 / Published: 21 January 2020
Background and Objectives: RAD51 plays an essential role in DNA repair via homologous recombination. RAD51 facilitates strand transfer between interrupted sequences and their undamaged homologies. Therefore, we studied the RAD51 mRNA expression levels in colorectal cancer (CRC), and evaluated the clinicopathological and prognostic significance of RAD51. Materials and Methods: The RAD51 expression was examined in 48 CRCs and paired adjacent non-tumor tissues. We further evaluated the survival to determine the prognostic value of RAD51 in our CRC and The Cancer Genome Atlas (TCGA) data. Results: We confirmed that the RAD51 expression in tumor tissues, compared with that of paired non-tumor tissues, was upregulated 2.5-fold. Additionally, the RAD51 expression was significantly associated with the T stage (p = 0.027). According to a higher T stage, the RAD51 expression showed an increasing trend. However, the RAD51 expression did not show a prognostic value statistically. Conclusions: We confirmed that RAD51 was upregulated in tumors and was significantly associated with the T stage. Although there was no statistically significant prognostic value found in our samples and TGCA data, our study will provide new insight for RAD51 in CRC. View Full-Text
Keywords: RAD51; colorectal cancer; double-stand breaks; cancer prognosis; clinical analysis RAD51; colorectal cancer; double-stand breaks; cancer prognosis; clinical analysis
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Lee, J.-H.; Bae, A.-N.; Jung, S.-J. Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer. Medicina 2020, 56, 48.

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