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Open AccessArticle

Functional and Structural Reliability of Optic Nerve Head Measurements in Healthy Eyes by Means of Optical Coherence Tomography Angiography

1
Vitreoretinal Unit, Bristol Eye Hospital, University of Bristol, Bristol BS8 1TH, UK
2
Eye Clinic, Polytechnic University of Marche, 60126 Ancona, Italy
3
Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. d’Annunzio Chieti-Pescara, 66100 Chieti, Italy
4
Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, University G. d’Annunzio Chieti-Pescara, 66100 Chieti, Italy
5
Department of Economic Studies, University G. d’Annunzio Chieti-Pescara, 66100 Chieti, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work and should be considered as co-first authors.
Medicina 2020, 56(1), 44; https://doi.org/10.3390/medicina56010044
Received: 12 November 2019 / Revised: 9 January 2020 / Accepted: 14 January 2020 / Published: 20 January 2020
(This article belongs to the Special Issue Imaging in Retinal Diseases)
Background and Objectives: the aim of the study was to evaluate the repeatability and reproducibility of optical microangiography (OMAG)-based optical coherence tomography angiography (OCTA) in the optic nerve head (ONH) and radial peripapillary capillary (RPC) perfusion assessment of healthy eyes. Materials and Methods: in this observational study, a total of 40 healthy subjects underwent ONH evaluation, using an OMAG-based OCTA system at baseline (T0), after 30 min (T1), and after 7 days (T2). The main outcome measures were the vessel density (VD) and flux index (FI) of the RPCs, as well as peri-papillary retinal nerve fibre layer (pRNFL) thickness. The analysis was performed by two observers independently. The coefficient of repeatability (CR), within the subject coefficient of variation (CVw) and intrasession correlation coefficient (ICC), to evaluate intrasession repeatability of measurements was calculated for each observer. Results: the high intrasession and intersession repeatability and reproducibility were assessed in the two observers for all three outcome measures. Of note, the CRs for the first and the second observer were 0.011 (95% confidence interval (CI) 0.009–0.014) and 0.016 (95% CI 0.013–0.020) for FI, 0.016 (95% CI 0.013–0.021) and 0.017 (95% CI 0.014–0.021) for VD, and 2.400 (95% CI 1.948–3.092) and 3.732 (95% CI 3.064–4.775) for pRNFL thickness, respectively. The agreement between them was excellent for pRNFL assessment and very good for FI and VD. Conclusion: OCTA has a great potential in the accurate assessment of ONH and peri-papillary microcirculation. It allows for repeated and reproducible measurements without multiple scans-related bias, thus guaranteeing an independent operator analysis with good reproducibility and repeatability. View Full-Text
Keywords: optical coherence tomography angiography; optic nerve head perfusion; optic nerve head vessel density; optical microangiography; repeatability of imaging tools optical coherence tomography angiography; optic nerve head perfusion; optic nerve head vessel density; optical microangiography; repeatability of imaging tools
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Mastropasqua, R.; D’Aloisio, R.; Agnifili, L.; Zuppardi, E.; Di Marzio, G.; Di Nicola, M.; Porreca, A.; Guarini, D.; Totta, M.; Brescia, L.; Di Antonio, L. Functional and Structural Reliability of Optic Nerve Head Measurements in Healthy Eyes by Means of Optical Coherence Tomography Angiography. Medicina 2020, 56, 44.

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