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Open AccessArticle

Evaluation of Maternal and Neonatal Outcomes of Assisted Reproduction Technology: A Retrospective Cohort Study

Department of Obstetrics and Gynecology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-0008, Japan
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Author to whom correspondence should be addressed.
Medicina 2020, 56(1), 32; https://doi.org/10.3390/medicina56010032
Received: 18 September 2019 / Revised: 24 December 2019 / Accepted: 13 January 2020 / Published: 15 January 2020
(This article belongs to the Section Obstetrics and Gynecology)
Background: To evaluate maternal and neonatal outcomes of assisted reproductive technology (ART). Materials and Methods: Pregnant women registered from 2015 through 2017 (n = 6994) at five perinatal centers that managed high-risk pregnancies in Mie, Japan, retrospectively. Rates of preterm birth (<37 gestational weeks), early onset preeclampsia (<34 gestational weeks), late onset preeclampsia (≥34 gestational weeks), low-lying placenta, placenta previa, placenta accreta, placental abruption, atonic bleeding, uterine rupture, and amniotic fluid embolism after ART were evaluated. ART was defined as in vitro fertilization and micro-fertilization. Fisher’s exact test, Mann–Whitney’s U test, and logistic regression analysis were used to analyze the data. Results: Rates of obstetrical complications including low-lying placenta, placenta previa, placenta accreta, and atonic bleeding were increased with ART compared to those with the control. Particularly, ART was associated with a significantly increased rate of placenta accreta (adjusted odds ratio: 7.35, 95% confidence interval (CI): 3.20–16.6) and significantly decreased rate of placental abruption (adjusted odds ratio: 0.24, 95% CI: 0.07–0.61). Conclusions: This study showed that ART may reduce placental abruption and increase placenta previa. There is a possibility that the placenta attaches deeper in the myometrium because of ART. View Full-Text
Keywords: maternal fetal medicine; assisted reproductive technology; maternal outcomes; neonatal outcomes maternal fetal medicine; assisted reproductive technology; maternal outcomes; neonatal outcomes
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Tanaka, H.; Tanaka, K.; Osato, K.; Kusaka, H.; Maegawa, Y.; Taniguchi, H.; Ikeda, T. Evaluation of Maternal and Neonatal Outcomes of Assisted Reproduction Technology: A Retrospective Cohort Study. Medicina 2020, 56, 32.

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