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Open AccessArticle

The Role of Cardiac T-Cadherin in the Indicating Heart Failure Severity of Patients with Non-Ischemic Dilated Cardiomyopathy

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Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, 01513 Vilnius, Lithuania
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Institute of Biochemistry, Life Sciences Center, Vilnius University, 01513 Vilnius, Lithuania
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Department of Medicine, University of California, San Diego, CA 92093, USA
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Department of Regenerative Medicine, State Research Institute, Center for Innovative Medicine, 08410 Vilnius, Lithuania
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Center of Cardiac Surgery, Clinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, 01513 Vilnius, Lithuania
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Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 01513 Vilnius, Lithuania
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Institute of Data Science and Digital Technologies, Faculty of Mathematics and Informatics, Vilnius University, 01513 Vilnius, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2020, 56(1), 27; https://doi.org/10.3390/medicina56010027
Received: 13 November 2019 / Revised: 19 December 2019 / Accepted: 7 January 2020 / Published: 9 January 2020
Background and objectives: T-cadherin (T-cad) is one of the adiponectin receptors abundantly expressed in the heart and blood vessels. Experimental studies show that T-cad sequesters adiponectin in cardiovascular tissues and is critical for adiponectin-mediated cardio-protection. However, there are no data connecting cardiac T-cad levels with human chronic heart failure (HF). The aim of this study was to assess whether myocardial T-cad concentration is associated with chronic HF severity and whether the T-cad levels in human heart tissue might predict outcomes in patients with non-ischemic dilated cardiomyopathy (NI-DCM). Materials and Methods: 29 patients with chronic NI-DCM and advanced HF were enrolled. Patients underwent regular laboratory investigations, echocardiography, coronary angiography, and right heart catheterization. TNF-α and IL6 in serum were detected by enzyme-linked immunosorbent assay (ELISA). Additionally, endomyocardial biopsies were obtained, and the levels of T-cad were assessed by ELISA and CD3, CD45Ro, CD68, and CD4- immunohistochemically. Mean pulmonary capillary wedge pressure (PCWP) was used as a marker of HF severity, subdividing patients into two groups: mean PCWP > 19 mmHg vs. mean PCWP < 19 mmHg. Patients were followed-up for 5 years. The study outcome was composite: left ventricular assist device implantation, heart transplantation, or death from cardiovascular causes. Results: T-cad shows an inverse correlation with the mean PCWP (rho = −0.397, p = 0.037). There is a tendency towards a lower T-cad concentration in patients with more severe HF, as indicated by the mean PCWP > 19 mmHg compared to those with mean PCWP ≤ 19 mmHg (p = 0.058). Cardiac T-cad levels correlate negatively with myocardial CD3 cell count (rho = −0.423, p = 0.028). Conclusions: Univariate Cox regression analysis did not prove T-cad to be an outcome predictor (HR = 1, p = 0.349). However, decreased T-cad levels in human myocardium can be an additional indicator of HF severity. T-cad in human myocardium has an anti-inflammatory role. More studies are needed to extend the role of T-cad in the outcome prediction of patients with NI-DCM. View Full-Text
Keywords: adiponectin; advanced heart failure; non-ischemic dilated cardiomyopathy; T-cadherin adiponectin; advanced heart failure; non-ischemic dilated cardiomyopathy; T-cadherin
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Baltrūnienė, V.; Rinkūnaitė, I.; Bogomolovas, J.; Bironaitė, D.; Kažukauskienė, I.; Šimoliūnas, E.; Ručinskas, K.; Puronaitė, R.; Bukelskienė, V.; Grabauskienė, V. The Role of Cardiac T-Cadherin in the Indicating Heart Failure Severity of Patients with Non-Ischemic Dilated Cardiomyopathy. Medicina 2020, 56, 27.

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