Next Article in Journal
Parameters of Oxidative and Inflammatory Status in a Three-Month Observation of Patients with Acute Myocardial Infarction Undergoing Coronary Angioplasty—A Preliminary Study
Next Article in Special Issue
Factors Affecting Psychological Stress in Healthcare Workers with and without Chronic Pain: A Cross-Sectional Study Using Multiple Regression Analysis
Previous Article in Journal
The Effect of Frankel’s Stabilization Exercises and Stabilometric Platform in the Balance in Elderly Patients: A Randomized Clinical Trial
Previous Article in Special Issue
Movement Control Impairment and Low Back Pain: State of the Art of Diagnostic Framing
Open AccessReview

Molecular Basis of Cancer Pain Management: An Updated Review

Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), Pulau Pinang 11800, Malaysia
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(9), 584; https://doi.org/10.3390/medicina55090584
Received: 29 June 2019 / Revised: 5 September 2019 / Accepted: 9 September 2019 / Published: 12 September 2019
(This article belongs to the Special Issue Chronic Pain Management)
Pain can have a significantly negative impact on the quality of life of patients. Therefore, patients may resort to analgesics to relieve the pain. The struggle to manage pain in cancer patients effectively and safely has long been an issue in medicine. Analgesics are the mainstay treatment for pain management as they act through various methods on the peripheral and central pain pathways. However, the variability in the patient genotypes may influence a drug response and adverse drug effects that follow through. This review summarizes the observed effects of analgesics on UDP-glucuronosyl (UGT) 2B7 isoenzyme, cytochrome P450 (CYP) 2D6, μ-opioid receptor μ 1 (OPRM1), efflux transporter P-glycoprotein (P-gp) and ATP-binding cassette B1 ABCB1/multiple drug resistance 1 (MDR1) polymorphisms on the mechanism of action of these drugs in managing pain in cancer. Furthermore, this review article also discusses the responses and adverse effects caused by analgesic drugs in cancer pain management, due to the inter-individual variability in their genomes. View Full-Text
Keywords: cancer; pain management; analgesics; adverse drug effects; polymorphism cancer; pain management; analgesics; adverse drug effects; polymorphism
Show Figures

Graphical abstract

MDPI and ACS Style

V. Subramaniam, A.; Salem Yehya, A.H.; Oon, C.E. Molecular Basis of Cancer Pain Management: An Updated Review. Medicina 2019, 55, 584.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop