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The Skin in Celiac Disease Patients: The Other Side of the Coin

1
Digestive Physiopathology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
2
Dermatology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
3
JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA
4
Clemson University School of Health Research, Clemson University, Clemson, SC 29634, USA
5
Dermatology Unit “Daniele Innocenzi”, Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, 04110 Terracina, Italy
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(9), 578; https://doi.org/10.3390/medicina55090578
Received: 31 May 2019 / Revised: 13 August 2019 / Accepted: 5 September 2019 / Published: 9 September 2019
(This article belongs to the Special Issue Advances in Celiac Disease)
Celiac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine and is characterized by atrophy of intestinal villi. The manifestations of the disease improve following a gluten-free diet (GFD). CD is associated with various extra-intestinal diseases. Several skin manifestations are described in CD patients. The present paper reviews all CD-associated skin diseases reported in the literature and tries to analyze the pathogenic mechanisms possibly involved in these associations. Different hypotheses have been proposed to explain the possible mechanisms involved in every association between CD and cutaneous manifestations. An abnormal small intestinal permeability seems to be implicated in various dermatological manifestations. However, most of the associations between CD and cutaneous diseases is based on case reports and case series and a few controlled studies. To better assess the real involvement of the cutaneous district in CD patients, large multicentric controlled clinical trials are required. View Full-Text
Keywords: gluten; gut; enteropathy; gluten-free diet; level of evidences gluten; gut; enteropathy; gluten-free diet; level of evidences
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MDPI and ACS Style

Abenavoli, L.; Dastoli, S.; Bennardo, L.; Boccuto, L.; Passante, M.; Silvestri, M.; Proietti, I.; Potenza, C.; Luzza, F.; Nisticò, S.P. The Skin in Celiac Disease Patients: The Other Side of the Coin. Medicina 2019, 55, 578. https://doi.org/10.3390/medicina55090578

AMA Style

Abenavoli L, Dastoli S, Bennardo L, Boccuto L, Passante M, Silvestri M, Proietti I, Potenza C, Luzza F, Nisticò SP. The Skin in Celiac Disease Patients: The Other Side of the Coin. Medicina. 2019; 55(9):578. https://doi.org/10.3390/medicina55090578

Chicago/Turabian Style

Abenavoli, Ludovico; Dastoli, Stefano; Bennardo, Luigi; Boccuto, Luigi; Passante, Maria; Silvestri, Martina; Proietti, Ilaria; Potenza, Concetta; Luzza, Francesco; Nisticò, Steven P. 2019. "The Skin in Celiac Disease Patients: The Other Side of the Coin" Medicina 55, no. 9: 578. https://doi.org/10.3390/medicina55090578

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