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Open AccessArticle

Lipid Profile Changes Induced by Chronic Administration of Anabolic Androgenic Steroids and Taurine in Rats

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Department of Functional Sciences, Division of Physiology and Neuroscience, “Carol Davila” University of Medicine and Pharmacy, 050470 Bucharest, Romania
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“Victor Babeş” National Institute of Research-Development in the Pathology Domain, 050096 Bucharest, Romania
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Department of Lipoproteins and Atherosclerosis, “Nicolae Simionescu” Institute of Cellular Biology and Pathology of the Romanian Academy, 030167 Bucharest, Romania
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Department of Endocrinology, “C. I. Parhon” National Institute of Endocrinology, “Carol Davila” University of Medicine and Pharmacy, 050470 Bucharest, Romania
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Department of Neurology, “Colentina” Clinical Hospital, “Carol Davila” University of Medicine and Pharmacy, 020350 Bucharest, Romania
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Department of Dermatology, “Prof. N.C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, 030167 Bucharest, Romania
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Department of Gastroenterology, “Elias” Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, 011461 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(9), 540; https://doi.org/10.3390/medicina55090540
Received: 30 June 2019 / Revised: 22 August 2019 / Accepted: 22 August 2019 / Published: 27 August 2019
Background and Objectives: Anabolic androgenic steroids (AAS), used as a therapy in various diseases and abused in sports, are atherogenic in supraphysiological administration, altering the plasma lipid profile. Taurine, a conditionally-essential amino acid often used in dietary supplements, was acknowledged to delay the onset and progression of atherogenesis, and to mitigate hyperlipidemia. The aim of the present study was to verify if taurine could prevent the alterations induced by concomitant chronic administration of high doses of AAS nandrolone decanoate (DECA) in rats. Materials and Methods: Thirty-two male Wistar rats, assigned to 4 equal groups, were treated for 12 weeks either with DECA (A group), taurine (T group), both DECA and taurine (AT group) or vehicle (C group). Plasma triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), hepatic triglycerides (TGh) and liver non-esterified fatty acids (NEFA) were then determined. Results: DECA elevated TG level in A group vs. control (p = 0.01), an increase prevented by taurine association in AT group (p = 0.04). DECA decreased HDL-C in A group vs. control (p = 0.02), while taurine tended to increase it in AT group. DECA decreased TGh (p = 0.02) in A group vs. control. Taurine decreased TGh in T (p = 0.004) and AT (p < 0.001) groups vs. control and tended to lower NEFA (p = 0.08) in AT group vs. A group. Neither DECA, nor taurine influenced TC and LDL-C levels. Conclusions: Taurine partially prevented the occurrence of DECA negative effects on lipid profile, suggesting a therapeutic potential in several conditions associated with chronic high levels of plasma androgens, such as endocrine disorders or AAS-abuse. View Full-Text
Keywords: anabolic androgenic steroids; AAS; nandrolone decanoate; DECA; taurine; lipids; triglycerides; HDL-C; cholesterol; lipoprotein anabolic androgenic steroids; AAS; nandrolone decanoate; DECA; taurine; lipids; triglycerides; HDL-C; cholesterol; lipoprotein
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Rosca, A.; Stancu, C.S.; Badiu, C.; Popescu, B.O.; Mirica, R.; Căruntu, C.; Gologan, S.; Voiculescu, S.E.; Zagrean, A.-M. Lipid Profile Changes Induced by Chronic Administration of Anabolic Androgenic Steroids and Taurine in Rats. Medicina 2019, 55, 540.

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