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Open AccessReview

Component-Resolved Diagnosis in Food Allergies

Pediatric and Neonatology Unit, Imola Hospital, 40026 Imola, Italy
Pediatric Unit, Civic Hospital, 60019 Senigallia, Italy
Pediatric Unit, Department of Medical and Surgical Sciences (DIMEC), S.Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
Author to whom correspondence should be addressed.
Medicina 2019, 55(8), 498;
Received: 22 May 2019 / Revised: 31 July 2019 / Accepted: 15 August 2019 / Published: 18 August 2019
(This article belongs to the Special Issue Food Allergies)
Component-resolved diagnostics (CRD) in food allergies is an approach utilized to characterize the molecular components of each allergen involved in a specific IgE (sIgE)-mediated response. In the clinical practice, CRD can improve diagnostic accuracy and assist the physician in many aspects of the allergy work-up. CRD allows for discriminatory co-sensitization versus cross-sensitization phenomena and can be useful to stratify the clinical risk associated with a specific sensitization pattern, in addition to the oral food challenge (OFC). Despite this, there are still some unmet needs, such as the risk of over-prescribing unnecessary elimination diets and adrenaline auto-injectors. Moreover, up until now, none of the identified sIgE cutoff have shown a specificity and sensitivity profile as accurate as the OFC, which is the gold standard in diagnosing food allergies. In light of this, the aim of this review is to summarize the most relevant concepts in the field of CRD in food allergy and to provide a practical approach useful in clinical practice. View Full-Text
Keywords: alfa-gal; casein; gliadin; lipid transfer protein; ovomucoid; parvalbumin; tropomyosin alfa-gal; casein; gliadin; lipid transfer protein; ovomucoid; parvalbumin; tropomyosin
MDPI and ACS Style

Calamelli, E.; Liotti, L.; Beghetti, I.; Piccinno, V.; Serra, L.; Bottau, P. Component-Resolved Diagnosis in Food Allergies. Medicina 2019, 55, 498.

AMA Style

Calamelli E, Liotti L, Beghetti I, Piccinno V, Serra L, Bottau P. Component-Resolved Diagnosis in Food Allergies. Medicina. 2019; 55(8):498.

Chicago/Turabian Style

Calamelli, Elisabetta; Liotti, Lucia; Beghetti, Isadora; Piccinno, Valentina; Serra, Laura; Bottau, Paolo. 2019. "Component-Resolved Diagnosis in Food Allergies" Medicina 55, no. 8: 498.

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