Next Article in Journal
The Quantitative ER Immunohistochemical Analysis in Breast Cancer: Detecting the 3 + 0, 4 + 0, and 5 + 0 Allred Score Cases
Next Article in Special Issue
Component-Resolved Diagnosis in Food Allergies
Previous Article in Journal
Targeting Microbiota: What Do We Know about It at Present?
Previous Article in Special Issue
Wheat Allergy in Children: A Comprehensive Update
Open AccessArticle

Influence of Atopic Dermatitis on Cow’s Milk Allergy in Children

Pediatric Unit, Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
“Giorgio Prodi” Cancer Research Center, University of Bologna, 40138 Bologna, Italy
Clinica Pediatrica, Department of Medicine and Surgery, University of Parma, 43100 Parma, Italy
Author to whom correspondence should be addressed.
Medicina 2019, 55(8), 460;
Received: 26 June 2019 / Revised: 25 July 2019 / Accepted: 7 August 2019 / Published: 10 August 2019
(This article belongs to the Special Issue Food Allergies)
Background and Objectives: Cow’s milk protein allergy (CMA) is the most common allergy in children. The natural history of CMA is generally favorable and the majority of children reach tolerance during childhood, even if studies show variable results. Atopic dermatitis (AD) is a complex disease from an immunological point of view. It is characterized by an impaired skin barrier function and is often the first clinical manifestation of the so-called “atopic march”. The aim of our study is to evaluate, in a cohort of children with CMA, if the presence of AD in the first months of life can influence the atopic status of patients, the tolerance acquisition to cow’s milk, the level of specific IgE (sIgE), and the sensitization towards food and/or inhalant allergens. Materials and Methods: We enrolled 100 children with a diagnosis of CMA referred to our Pediatric Allergology Unit, aged 1–24 months at the time of the first visit. Results: 71 children had AD and 29 did not. The mean follow-up was 5.28 years. The CMA manifestations were mainly cutaneous, especially in children with AD (91.6% vs. 51.7%; P < 0.001). Patients with AD showed higher rates of polysensitization to foods and higher levels of both total IgE and sIgE for milk, casein, wheat, peanuts, and cat dander at different ages when compared to patients without AD. We analyzed the presence of IgE sensitization for the main foods and inhalants at various ages in the two groups of patients: a statistically significant difference emerged in the two groups of patients for milk, yolk and egg white, hazelnut, peanuts, soybean, grass pollen and cat dander. Meanwhile, we did not find significant differences in terms of tolerance acquisition toward cow’s milk, which was nonetheless reached around 5 years of age in 61% of patients. The level of cow’s milk sIgE at the age of 5 years was significantly higher in the group of patients who did not acquire tolerance (38.38 vs. 5.22 kU/L; P < 0.0001). Conclusions: An early barrier deficiency appears to promote the development of allergic sensitization, but does not seem to influence the acquisition of tolerance. View Full-Text
Keywords: atopic dermatitis; children; cow’s milk allergy; food allergy; sensitization; tolerance atopic dermatitis; children; cow’s milk allergy; food allergy; sensitization; tolerance
Show Figures

Figure 1

MDPI and ACS Style

Giannetti, A.; Cipriani, F.; Indio, V.; Gallucci, M.; Caffarelli, C.; Ricci, G. Influence of Atopic Dermatitis on Cow’s Milk Allergy in Children. Medicina 2019, 55, 460.

AMA Style

Giannetti A, Cipriani F, Indio V, Gallucci M, Caffarelli C, Ricci G. Influence of Atopic Dermatitis on Cow’s Milk Allergy in Children. Medicina. 2019; 55(8):460.

Chicago/Turabian Style

Giannetti, Arianna; Cipriani, Francesca; Indio, Valentina; Gallucci, Marcella; Caffarelli, Carlo; Ricci, Giampaolo. 2019. "Influence of Atopic Dermatitis on Cow’s Milk Allergy in Children" Medicina 55, no. 8: 460.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop