Next Article in Journal
Influence of Atopic Dermatitis on Cow’s Milk Allergy in Children
Previous Article in Journal
Can Anhedonia Be Considered a Suicide Risk Factor? A Review of the Literature
Open AccessReview

Targeting Microbiota: What Do We Know about It at Present?

Riga Stradins University, Department of Internal Medicine, LV-1007 Riga, Latvia
Riga East Clinical University Hospital, LV-1038 Riga, Latvia
Riga Stradins University, Department of Infectology and Dermatology, LV-1007 Riga, Latvia
Author to whom correspondence should be addressed.
Medicina 2019, 55(8), 459;
Received: 26 June 2019 / Revised: 2 August 2019 / Accepted: 5 August 2019 / Published: 10 August 2019
The human microbiota is a variety of different microorganisms. The composition of microbiota varies from host to host, and it changes during the lifetime. It is known that microbiome may be changed because of a diet, bacteriophages and different processes for example, such as inflammation. Like all other areas of medicine, there is a continuous growth in the area of microbiology. Different microbes can reside in all sites of a human body, even in locations that were previously considered as sterile; for example, liver, pancreas, brain and adipose tissue. Presently one of the etiological factors for liver disease is considered to be pro-inflammatory changes in a host’s organism. There are lot of supporting data about intestinal dysbiosis and increased intestinal permeability and its effect on development of liver disease pointing to the gut–liver axis. The gut–liver axis affects pathogenesis of many liver diseases, such as chronic hepatitis B, chronic hepatitis C, alcoholic liver disease, non-alcoholic liver disease, non-alcoholic steatohepatitis, liver cirrhosis and hepatocellular carcinoma. Gut microbiota has been implicated in the regulation of brain health, emphasizing the gut–brain axis. Also, experiments with mice showed that microorganisms have significant effects on the blood–brain barrier integrity. Microbiota can modulate a variety of mechanisms through the gut–liver axis and gut–brain axis. Normal intestinal flora impacts the health of a host in many positive ways, but there is now significant evidence that intestinal microbiota, especially altered, have the ability to impact the pathologies of many diseases through different inflammatory mechanisms. At this point, many of the pathophysiological reactions in case of microbial disbyosis are still unclear. View Full-Text
Keywords: gut; microbiome; liver disease; CNS; neurodegenerative disease; probiotics gut; microbiome; liver disease; CNS; neurodegenerative disease; probiotics
MDPI and ACS Style

Derovs, A.; Laivacuma, S.; Krumina, A. Targeting Microbiota: What Do We Know about It at Present? Medicina 2019, 55, 459.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

Back to TopTop