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Neutrophil Extracellular Traps in the Establishment and Progression of Renal Diseases

1
Decanato de Ciencia y Tecnología, Universidad Autónoma de Guadalajara, Zapopan 45129, Mexico
2
Facultad de Medicina, Universidad Autónoma de Guadalajara, Zapopan 45129, Mexico
3
CONACyT-Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada #800 Col. Independencia, Guadalajara 44340, Mexico
4
Facultad de Medicina, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(8), 431; https://doi.org/10.3390/medicina55080431
Received: 11 June 2019 / Revised: 23 July 2019 / Accepted: 30 July 2019 / Published: 2 August 2019
Uncontrolled inflammatory and immune responses are often involved in the development of acute and chronic forms of renal injury. Neutrophils are innate immune cells recruited early to sites of inflammation, where they produce pro-inflammatory cytokines and release mesh-like structures comprised of DNA and granular proteins known as neutrophil extracellular traps (NETs). NETs are potentially toxic, contribute to glomerular injury, activate autoimmune processes, induce vascular damage, and promote kidney fibrosis. Evidence from multiple studies suggests that an imbalance between production and clearance of NETs is detrimental for renal health. Hence strategies aimed at modulating NET-associated processes could have a therapeutic impact on a myriad of inflammatory diseases that target the kidney. Here, we summarize the role of NETs in the pathogenesis of renal diseases and their mechanisms of tissue damage. View Full-Text
Keywords: kidney; AKI; autoimmunity; vasculitis; neutrophils; NETosis; NETs kidney; AKI; autoimmunity; vasculitis; neutrophils; NETosis; NETs
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MDPI and ACS Style

Salazar-Gonzalez, H.; Zepeda-Hernandez, A.; Melo, Z.; Saavedra-Mayorga, D.E.; Echavarria, R. Neutrophil Extracellular Traps in the Establishment and Progression of Renal Diseases. Medicina 2019, 55, 431.

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