Next Article in Journal
Conservative Rehabilitation Provides Superior Clinical Results Compared to Early Aggressive Rehabilitation for Rotator Cuff Repair: A Retrospective Comparative Study
Previous Article in Journal
Wheat Allergy in Children: A Comprehensive Update
Open AccessArticle

Supplementation of Adiantum capillus-veneris Modulates Alveolar Apoptosis under Hypoxia Condition in Wistar Rats Exposed to Exercise

1
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar 4741613534, Iran
2
Sport Science Program (SSP), College of Arts and Sciences (CAS), Qatar University, Doha 2713, Qatar
3
Faculty of Aerospace Medicine and Subsurface, Army Medical University, Tehran 611/14185, Iran
4
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz 5166616471, Iran
5
Department of Biological Sciences in Sport, Faculty of Sports Sciences and Health, Shahid Beheshti University, Tehran 1983969411, Iran
6
ISSEP Ksar Said, University of Manouba, Tunis 2010, Tunisia
7
Department of Exercise & Sport Science, University of North Carolina, Chapel Hill, NC 27599, USA
8
Laboratoire M2S, University of Rennes, EA 1274, F-35000 Rennes, France
*
Author to whom correspondence should be addressed.
These authors participated equally to this work.
Medicina 2019, 55(7), 401; https://doi.org/10.3390/medicina55070401
Received: 27 May 2019 / Revised: 13 July 2019 / Accepted: 18 July 2019 / Published: 23 July 2019
  |  
PDF [4923 KB, uploaded 25 July 2019]
  |  

Abstract

Background and Objectives: Several studies have reported that some conditions such as exercise and hypoxia induce DNA damage and dysfunction and apoptosis. Some plant foods contain numerous bioactive compounds and anti-inflammatory properties that can help fight DNA damage. Therefore, the current study evaluated the effect of supplementation of Adiantum capillus-veneris (ACV) extract on Bax/B-cell lymphoma 2 (Bcl-2) ratio apoptotic index and remodeling of pulmonary alveolar epithelial cells in lung tissue of healthy Wistar rats during stressful conditions (hypoxia). Materials and Methods: Twenty-seven Wistar male rats (four-week old, 72 ± 9 g) were randomly assigned into three groups: normoxic, sedentary, and not-supplemented (NG, n = 9); exercise and hypoxia and not-supplemented (HE, n = 9); and exercise and hypoxia and supplemented group (HS, n = 9). The NG remained sedentary in the normoxia environment for nine weeks. The HE group participated in a high-intensity (IT) program for six weeks, then remained sedentary in the hypoxia environment for three weeks. The low-pressure chamber simulated a ~2800 M altitude 24 h/d. HS participated in IT, then entered and remained sedentary in the hypoxia environment for three weeks, and they consumed 500 mg per kg of body weight ACV extract. Results: The Bax/Bcl-2 ratio of the HE group increased significantly (+50.27%, p ≤ 0.05), the average number of type I pneumocytes was reduced significantly (−18.85%, p ≤ 0.05), and the average number of type II pneumocytes was increased significantly (+14.69%, p ≤ 0.05). Also, after three weeks of consuming the ACV extract, the HS group in comparison with the HE group had their Bax/Bcl-2 ratio reduced significantly (−24.27%, p ≤ 0.05), the average number of type I pneumocytes increased significantly (+10.15%, p ≤ 0.05), and the average number of type II pneumocytes reduced significantly (−7.18%, p ≤ 0.05). Conclusion: The findings show that after three weeks of hypoxia following six weeks of high-intensity interval training in Wistar rats, the Bax/Bcl-2 ratio and the number of type II pneumocytes were increased and the number of type I pneumocytes was reduced significantly. These results strongly suggest that an apoptosis state was induced in the lung parenchyma, and consuming ACV extract modulated this state. View Full-Text
Keywords: respiratory disease; pathological apoptosis; Bax/Bcl-2 ratio; pneumocytes; exercise training respiratory disease; pathological apoptosis; Bax/Bcl-2 ratio; pneumocytes; exercise training
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Yadegari, M.; Sellami, M.; Riahy, S.; Mirdar, S.; Hamidian, G.; Saeidi, A.; Ben Abderrahman, A.; Hackney, A.C.; Zouhal, H. Supplementation of Adiantum capillus-veneris Modulates Alveolar Apoptosis under Hypoxia Condition in Wistar Rats Exposed to Exercise. Medicina 2019, 55, 401.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Medicina EISSN 1010-660X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top