Next Article in Journal
Supplementation of Adiantum capillus-veneris Modulates Alveolar Apoptosis under Hypoxia Condition in Wistar Rats Exposed to Exercise
Next Article in Special Issue
Influence of Atopic Dermatitis on Cow’s Milk Allergy in Children
Previous Article in Journal
Addition of 100 mg of Tramadol to 40 mL of 0.5% Ropivacaine for Interscalene Brachial Plexus Block Improves Postoperative Analgesia in Patients Undergoing Shoulder Surgeries as Compared to Ropivacaine Alone—A Randomized Controlled Study
Previous Article in Special Issue
Prevention of Food Allergy: The Significance of Early Introduction
Open AccessReview

Wheat Allergy in Children: A Comprehensive Update

1
Pediatric Unit, Department of Medical and Surgical Sciences, University of Bologna, 40139 Bologna, Italy
2
Clinica Pediatrica, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(7), 400; https://doi.org/10.3390/medicina55070400
Received: 21 June 2019 / Revised: 14 July 2019 / Accepted: 18 July 2019 / Published: 23 July 2019
(This article belongs to the Special Issue Food Allergies)
Gluten-related disorders are very common in pediatric patients. Wheat allergy is triggered by an immunoglobulin E (IgE)-dependent mechanism; its prevalence varies according to the age and region, and in Europe has been estimated to be lower than 1%. Many studies investigated the potential role of several external factors that can influence the risk to developing wheat allergy, but results are still inconclusive. It can be responsible for several clinical manifestations depending on the route of allergen exposure: food-dependent exercise-induced anaphylaxis (FDEIA), occupational rhinitis or asthma (also known as baker’s asthma), and contact urticaria. The prognosis of IgE-mediated wheat allergy in children is generally favorable, with the majority of children becoming tolerant by school age. Patients who experienced an anaphylactic reaction prior to 3 years of age and patients with higher level of wheat- or ω-5 gliadin-specific IgE antibodies seem to be at higher risk of persistent wheat allergy. The current management of patients is dietary avoidance. Nowadays, oral immunotherapy has been proposed for wheat allergy with promising results, even if further studies are necessary to establish the best protocol in order to promote tolerance in wheat-allergic children. View Full-Text
Keywords: anaphylaxis; asthma; food allergy; recombinant allergen; Triticum aestivum; wheat anaphylaxis; asthma; food allergy; recombinant allergen; Triticum aestivum; wheat
Show Figures

Figure 1

MDPI and ACS Style

Ricci, G.; Andreozzi, L.; Cipriani, F.; Giannetti, A.; Gallucci, M.; Caffarelli, C. Wheat Allergy in Children: A Comprehensive Update. Medicina 2019, 55, 400.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop