Next Article in Journal
Use of Plasmapheresis and Immunosuppressants to Treat Diffuse Alveolar Hemorrhage in a Patient with Granulomatosis with Polyangiitis
Next Article in Special Issue
An Experimental Study to Evaluate the Protective Effects of Solanum lycopersicum Seed Essential Oil on Diabetes-Induced Testicular Injuries
Previous Article in Journal
Association between the No-Reflow Phenomenon and Soluble CD40 Ligand Level in Patients with Acute ST-Segment Elevation Myocardial Infarction
Previous Article in Special Issue
Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle

Human Papillomavirus and Infertility

Santaros Fertility Center, Vilnius University Hospital Santaros Klinikos, Santariskiu Str. 2, 08661 Vilnius, Lithuania
Medicina Practica Laboratory, P. Baublio Str. 4, 08406 Vilnius, Lithuania
National Cancer Institute, Santariskiu Str. 1, 08660 Vilnius, Lithuania
Nature Research Centre, Akademijos Str. 2, 08412 Vilnius, Lithuania
Author to whom correspondence should be addressed.
Medicina 2019, 55(7), 377;
Received: 17 April 2019 / Revised: 28 June 2019 / Accepted: 11 July 2019 / Published: 15 July 2019
(This article belongs to the Special Issue Clinical Embryology and Reproductive Medicine)
PDF [446 KB, uploaded 17 July 2019]


Background and objectives. Human papillomavirus (HPV) is the most commonly sexually transmitted infection. Recent evidence suggests that an HPV infection may affect fertility. The aim of the study was to determine the prevalence of HPV infections among couples undergoing in vitro fertilization (IVF) and to identify their awareness of HPV. Material and Methods. A total of 200 samples were collected from couples who received IVF treatment during 2017–2018 in Vilnius University Hospital Santaros Klinikos (VUH SK) Santaros Fertility Centre (SFC). For HPV detection, cervical swabs from women and sperm samples from men were taken and a real time polymerase chain reaction (RT-PCR) was used for the identification of 14 high-risk HPV types. Sperm parameters were evaluated according to World Health Organization (WHO) recommendations for 2010. Research subjects answered an anonymous questionnaire to ascertain their knowledge of HPV. Results. After testing of HPV in couples undergoing IVF, it was found that 33 out of 100 couples (33%) were HPV positive. Of these, 19% of women (19/100) and 20% of men (20/100) tested positive. Using Fisher’s exact test, a statistically significant difference was found between HPV infections and abnormal sperm quality parameters (p = 0.023). Conclusions. HPV may have an impact in spermatogenesis, because an HPV infection was more frequently detected in men with abnormal sperm parameters. High-risk HPV 52 was the most common genotype among couples undergoing IVF treatment. View Full-Text
Keywords: HPV; in vitro fertilization; semen analysis; infertility; astenospermia HPV; in vitro fertilization; semen analysis; infertility; astenospermia

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Jeršovienė, V.; Gudlevičienė, Ž.; Rimienė, J.; Butkauskas, D. Human Papillomavirus and Infertility. Medicina 2019, 55, 377.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics



[Return to top]
Medicina EISSN 1010-660X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top