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Open AccessReview

Radioprotective Effect of Hesperidin: A Systematic Review

Department of Medical Physics, Tehran University of Medical Sciences (TUMS), Tehran 1416753955, Iran
Department of Physics, University of Guilan, Guilan 43714, Iran
Radiotherapy and Oncology Research Center, Cancer Institute, TUMS, Tehran 1416753955, Iran
Misan Radiotherapy Center, Misan Health Directorate, Ministry of Health/Environment, Misan 62010, Iraq
Department of Physiology, College of Medicine, University of Misan, Misan 62010, Iraq
Author to whom correspondence should be addressed.
Medicina 2019, 55(7), 370;
Received: 26 June 2019 / Revised: 10 July 2019 / Accepted: 11 July 2019 / Published: 12 July 2019
PDF [667 KB, uploaded 16 July 2019]


Background and objectives: Ionizing radiation (IR) has been of immense benefit to man, especially for medical purposes (diagnostic imaging and radiotherapy). However, the risks of toxicity in healthy normal cells, leading to cellular damage as well as early and late side effects, have been major drawbacks. The aim of this study was to evaluate the radioprotective effect of hesperidin against IR-induced damage. Materials and Methods: The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were applied in reporting this study. A search was conducted using the electronic databases PubMed, Scopus, Embase, Google Scholar, and for information about completed or ongoing clinical trials. Results: From our search results, 24 studies involving rats, mice, and cultured human and animal cells were included. An experimental case—control design was used in all studies. The studies showed that the administration of hesperidin reduced oxidative stress and inflammation in all investigated tissues. Furthermore, it increased 30-day and 60-day survival rates and protected against DNA damage. The best radioprotection was obtained when hesperidin was administered before irradiation. Conclusions: The results of the included studies support the antioxidant, anti-inflammatory, and antiapoptotic abilities of hesperidin as a potential radioprotective agent against IR-induced damage. We recommend future clinical trials for more insights. View Full-Text
Keywords: Hesperidin; radiation protection; radiotherapy; DNA damage; ionizing radiation Hesperidin; radiation protection; radiotherapy; DNA damage; ionizing radiation

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Musa, A.E.; Omyan, G.; Esmaely, F.; Shabeeb, D. Radioprotective Effect of Hesperidin: A Systematic Review. Medicina 2019, 55, 370.

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