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Association of NOTCH3 Gene Polymorphisms with Ischemic Stroke and Its Subtypes: A Meta-Analysis

1
Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Bandar Barat, 31900 Kampar, Perak, Malaysia
2
Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Musk Avenue, Kelvin Grove, QLD 4059, Australia
3
Department of Medicine and Clinical Research Centre, Seberang Jaya Hospital, Jalan Tun Hussein Onn, 13700 Seberang Jaya, Pulau Pinang, Malaysia
4
Department of Medicine and Clinical Research Centre, Taiping Hospital, Jalan Tamingsari, 34000 Taiping, Perak, Malaysia
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(7), 351; https://doi.org/10.3390/medicina55070351
Received: 13 April 2019 / Revised: 26 June 2019 / Accepted: 2 July 2019 / Published: 8 July 2019
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Abstract

Background and objectives: NOTCH3 gene variations play a significant role in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). However, the role of NOTCH3 gene polymorphisms in the risk of ischemic stroke, and its subtypes such as atherothrombotic or lacunar strokes, remains unclear. Aims: Hence, we carried out a meta-analysis to examine whether the NOTCH3 rs1043994, rs1044009 and rs3815188 polymorphisms are associated with ischemic stroke and its major subtypes. Materials and Methods: All relevant studies were systematically screened and meta-analyzed using Review Manager (Revman) version 5.3. The strength of the association between NOTCH3 polymorphisms and ischemic stroke risk and its subtypes were measured as odds ratios and 95% confidence intervals, under different genetic models. Results: A total of ten studies were identified, five of which considered NOTCH3 rs1043994 (2077 cases/2147 controls), five of which considered NOTCH3 rs1044009 (2315 cases/3053 controls), and nine of which considered NOTCH3 rs3815188 (2819 cases/2769 controls). These studies were meta-analyzed for their association with ischemic stroke risk. Four studies (874 cases/2002 controls) of the NOTCH3 rs3815188 polymorphism and three studies of the NOTCH3 rs1043994 (643 cases/1552 controls) polymorphism were meta-analyzed for lacunar stroke risk. Three studies (1013 cases/1972 controls) of the NOTCH3 rs3815188 polymorphism were meta-analyzed for atherothrombotic stroke risk. The meta-analysis results showed a lack of association between all of the studied polymorphisms and the risk of ischemic stroke and its major subtypes (i.e., atherothrombotic and lacunar). Conclusions: NOTCH3 polymorphisms are not significantly associated with the risk of ischemic stroke and its subtypes (p < 0.05). View Full-Text
Keywords: meta-analysis; NOTCH3; single nucleotide polymorphisms (SNPs); ischemic stroke; lacunar stroke; atherothrombotic stroke meta-analysis; NOTCH3; single nucleotide polymorphisms (SNPs); ischemic stroke; lacunar stroke; atherothrombotic stroke
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MDPI and ACS Style

Keat Wei, L.; R. Griffiths, L.; Looi, I.; Wee Kooi, C. Association of NOTCH3 Gene Polymorphisms with Ischemic Stroke and Its Subtypes: A Meta-Analysis. Medicina 2019, 55, 351.

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