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High SPOCK1 Expression Is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer

1,†, 2,†, 1,3, 2,4,5, 2,4,5, 2,4,5,*,‡ and 1,3,4,‡
1
Department of Surgical Pathology, Changhua Christian Hospital, Changhua 50006, Taiwan
2
Department of Urology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
3
Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 35664, Taiwan
4
School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
5
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this manuscript.
These authors contributed equally to this manuscript.
Medicina 2019, 55(7), 343; https://doi.org/10.3390/medicina55070343
Received: 29 April 2019 / Revised: 25 June 2019 / Accepted: 4 July 2019 / Published: 5 July 2019
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Abstract

Background and objectives: Prostate cancer (PCa) is a common malignancy in males and has a relatively slower progression than other cancers. Our goal was to evaluate the clinical role of SPARC (secreted protein acidic and cysteine rich, osteonectin), cwcv, and kazal-like domains’ proteoglycan 1 (SPOCK1) in PCa. Materials and Methods: SPOCK1 expression was studied through the immunohistochemical staining of specimens from 71 patients with PCa. The correlation between SPOCK1 expression and clinicopathological features was quantitatively analyzed. We used Kaplan–Meier analysis and Cox proportional hazard models to analyze the prognostic value. Results: Of 71 PCa patients, high SPOCK1 expression was more likely to be seen in those with an advanced stage (p = 0.018) of the disease and an advanced tumor (T) value (p = 0.014). Patients in Gleason grade groups 3 and 4 had significantly higher SPOCK1 expression (p = 0.044 and 0.003, respectively) compared to those of Gleason grade group 1. However, this trend was not observed in patients in Gleason grade group 5. For the survival analysis, although it was not statistically significant, patients with a high SPOCK1 expression had a shorter median overall survival (6.2 years) compared to those with low expression (7.8 years). Conclusions: High SPOCK1 expression may be related to advanced clinicopathological features and possibly a poor prognosis. Further analysis with a larger patient base would help clarify this issue. View Full-Text
Keywords: SPOCK1; prostate cancer; Gleason grade; survival SPOCK1; prostate cancer; Gleason grade; survival
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MDPI and ACS Style

Chen, M.-L.; Ho, C.-J.; Yeh, C.-M.; Chen, S.-L.; Sung, W.-W.; Wang, S.-C.; Chen, C.-J. High SPOCK1 Expression Is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer. Medicina 2019, 55, 343.

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