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Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms

1
Clinic of Neurosurgery, Clinical Center Niš, Zorana Đinđića 48, 18000 Niš, Serbia
2
Faculty of Medicine, University of Niš, Zorana Đinđića 81,18000 Niš, Serbia
3
Institute of Pathology, Clinical Center Niš, Zorana Đinđića 48, 18000 Niš, Serbia
*
Authors to whom correspondence should be addressed.
Medicina 2019, 55(7), 338; https://doi.org/10.3390/medicina55070338
Received: 9 February 2019 / Revised: 29 June 2019 / Accepted: 1 July 2019 / Published: 3 July 2019
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Abstract

Background and Objectives: Intracranial hemorrhage caused by the rupture of brain aneurysms occurs in almost 10 per 100,000 people whereas the incidence of such aneurysms is significantly higher, accounting for 4–9%. Linking certain factors to cerebral aneurysm rupture could help in explaining the significantly lower incidence of their rupture compared to their presence. The aim of this study is to determine the association between the corresponding circle of Willis configurations and rupture of cerebral aneurysms. Materials and Methods: A group of 114 patients treated operatively for aruptured cerebral aneurysm and a group of 56 autopsied subjects were involved in the study. Four basic types of the circle of Willis configurations were formed—two symmetric types A and C, and two asymmetric types B and D. Results: A statistically significantly higher presence of asymmetry of the circle of Willis was determined in the group of surgically-treated subjects (p = 0.001),witha significant presence of asymmetric Type B in this group (p < 0.001). The changeson the A1 segment in the group of surgically-treated subjects showed a statistically significant presence compared to the group of autopsied subjects (p = 0.001). Analyzing the presence of symmetry of the circle of Willis between the two groups, that is, the total presence of symmetric types A and C, indicated their statistically significant presence in the group of autopsied patients (p < 0.001). Conclusions: Changes such as hypoplasia or aplasia of A1 and the resulting asymmetry of the circle of Willis directly affect the possibility of the rupture of cerebral aneurysms. Detection of the corresponding types of the circle of Willis after diagnostic examination can be the basis for the development of a protocol for monitoring such patients. View Full-Text
Keywords: cerebral aneurysms; circle of Willis cerebral aneurysms; circle of Willis
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MDPI and ACS Style

Stojanović, N.N.; Kostić, A.; Mitić, R.; Berilažić, L.; Radisavljević, M. Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms. Medicina 2019, 55, 338.

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