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Open AccessCase Report

Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis

1
Department of Respiratory Medicine, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan
2
Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan
3
Gunma University Graduate School of Health Sciences, Maebashi 371-8514, Japan
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(7), 336; https://doi.org/10.3390/medicina55070336
Received: 20 April 2019 / Revised: 18 June 2019 / Accepted: 25 June 2019 / Published: 3 July 2019
(This article belongs to the Special Issue Latest Advances in the Treatment of Sinus and Nasal Diseases)
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Abstract

A 56-year-old man with severe asthma underwent bronchial thermoplasty (BT). However, his asthma exacerbated and hypereosinophilia developed 2 months later, thus necessitating oral corticosteroid (OCS) therapy. Six months after BT, a diagnosis of severe asthma with eosinophilic chronic rhinosinusitis (ECRS) was made and benralizumab treatment was initiated; the blood eosinophil count subsequently decreased and lung function improved, thereby permitting OCS dose tapering. Surprisingly, benralizumab both reduced nasal polyps and ameliorated ECRS. Thus, benralizumab may be a useful drug for the rapid treatment of severe asthma with ECRS, especially in patients with hypereosinophilia. View Full-Text
Keywords: severe asthma; benralizumab; hypereosinophilia; bronchial thermoplasty; eosinophilic chronic rhinosinusitis severe asthma; benralizumab; hypereosinophilia; bronchial thermoplasty; eosinophilic chronic rhinosinusitis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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MDPI and ACS Style

Tsurumaki, H.; Matsuyama, T.; Ezawa, K.; Koga, Y.; Yatomi, M.; Aoki-Saito, H.; Chikamatsu, K.; Hisada, T. Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis. Medicina 2019, 55, 336.

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