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Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction

1
Department of Medical Biochemistry, Gaziantep University Medical Faculty Hospital, 27310 Gaziantep, Turkey
2
Department of Obstetrics and Gynecology, Gaziantep University Medical Faculty Hospital, 27310 Gaziantep, Turkey
3
Balıkesir Atatürk State Hospital, 10100 Balıkesir, Turkey
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(7), 328; https://doi.org/10.3390/medicina55070328
Received: 2 May 2019 / Revised: 21 June 2019 / Accepted: 27 June 2019 / Published: 2 July 2019
(This article belongs to the Special Issue Clinical Embryology and Reproductive Medicine)
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Abstract

Background and objectives: In this study, the aim was to investigate Urotensin 2 (U-II) levels and oxidant/antioxidant system parameters in pregnancies with intrauterine growth restriction (IUGR). Materials and Methods: A total of 36 healthy, pregnant women who had not been diagnosed with IUGR and 36 pregnant women who had been diagnosed with IUGR at the Obstetrics and Gynecology Outpatient Clinic at Gaziantep University Hospital were enrolled in this study. The serum total antioxidant status (TAS), total oxidant status (TOS), thiol-disulfide levels, U-II measurements, and oxidative stress index (OSI) calculations were carried out at the biochemistry laboratory at Gaziantep University. Results: According to this study, there was no statistically significant difference between the group with IUGR and the control group of healthy, pregnant women in terms of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, native thiol/total thiol, and U-II values. There was, however, a positive linear correlation between TOS and total thiol levels in the group with IUGR (p = 0.021, r = 0.384), and a positive linear correlation between OSI and total thiol values in the control group (p = 0.049, r = 0.330). In addition, there was a negative correlation between disulfide levels and gestational weeks at birth in the group with IUGR (p = 0.027, r = 0.369). Conclusions: Consequently, there was no significant difference between the control group and the group with pregnancies complicated by idiopathic IUGR in terms of serum oxidant/antioxidant system parameters and U-II levels. It is necessary to conduct more extensive studies evaluating placental, maternal, and fetal oxidative stress in conjunction in order to investigate the role of oxidative stress in IUGR. View Full-Text
Keywords: intrauterine growth restriction; oxidative stress; thiol-disulfide; Urotensin 2 intrauterine growth restriction; oxidative stress; thiol-disulfide; Urotensin 2
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Celik, E.; Taysi, S.; Sucu, S.; Ulusal, H.; Sevincler, E.; Celik, A. Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction. Medicina 2019, 55, 328.

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