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Open AccessArticle

Protective Effect of Melatonin Against Radiotherapy-Induced Small Intestinal Oxidative Stress: Biochemical Evaluation

1
Department of Medical Physics, Tehran University of Medical Sciences (TUMS), International Campus, Tehran 1416753955, Iran
2
Research Center for Molecular and Cellular Imaging, TUMS, Tehran 1416753955, Iran
3
Al-Sadder Teaching Hospital, Department of Neurophysiology, Misan 62010, Iraq
4
University of Misan, Faculty of Medicine, Department of Physiology, Misan 62010, Iraq
5
University of Misan, Faculty of Medicine, Department of Medicine, Misan 62010, Iraq
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(6), 308; https://doi.org/10.3390/medicina55060308
Received: 10 May 2019 / Revised: 21 June 2019 / Accepted: 21 June 2019 / Published: 25 June 2019
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Abstract

Background and Objectives: Radiation enteritis is a common side effect after radiotherapy for abdominal and pelvic malignancies. The aim of the present study was to investigate the protective effect of melatonin, known for its free radical scavenging ability, against radiotherapy-induced small intestinal oxidative damage. Materials and Methods: Thirty male Wistar rats were randomly assigned to six groups (5 rats in each) as follows: Group I (control group) rats received neither radiation nor melatonin; group II rats received only 8 Gy single dose of gamma radiation to their abdomen and pelvis regions; group III (administered with only 50 mg/kg melatonin); group IV (administered with only 100 mg/kg melatonin); group V (50 mg/kg melatonin + 8 Gy radiation), group VI (100 mg/kg melatonin + 8 Gy radiation). All rats were sacrificed after 5 days for biochemical assessments of their intestinal tissues. Results: Treatment with melatonin post irradiation significantly reduced malondialdehyde (MDA) levels as well as increased both superoxide dismutase (SOD) and catalase (CAT) activities of the irradiated intestinal tissues. In addition, melatonin administration with different doses pre irradiation led to protection of the tissues. Moreover, the 100 mg/kg dose was more effective compared to 50 mg/kg. Conclusions: The results of our study suggest that melatonin has a potent protective effect against radiotherapy-induced intestinal damage, by decreasing oxidative stress and increasing antioxidant enzymes. We recommend future clinical trials for more insights. View Full-Text
Keywords: radiotherapy; melatonin; small intestine; oxidative stress; ionizing radiation radiotherapy; melatonin; small intestine; oxidative stress; ionizing radiation
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Musa, A.E.; Shabeeb, D.; Alhilfi, H.S.Q. Protective Effect of Melatonin Against Radiotherapy-Induced Small Intestinal Oxidative Stress: Biochemical Evaluation. Medicina 2019, 55, 308.

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