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Interplay between STAT3, Cell Adhesion Molecules and Angiogenesis-Related Parameters in Gastric Carcinoma. Does STAT3 Really Have a Prognostic Value?

1
Department of Pathology, Faculty of Medicine, University of Niš, 18000 Niš, Serbia
2
Center for Pathology, Clinical Center Niš, 18000 Niš, Serbia
3
Faculty of Medicine, University of Niš, 18000 Niš, Serbia
4
Department of Histology and Embryology, Faculty of Medicine, University of Niš, 18000 Niš, Serbia
5
Department of Anatomy, Faculty of Medicine, University of Niš, 18000 Niš, Serbia
6
Department of Internal Medicine, Faculty of Medicine, University of Niš, 18000 Niš, Serbia
7
Clinic of Internal Medicine, Clinical Center Niš, 18000 Niš, Serbia
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(6), 300; https://doi.org/10.3390/medicina55060300
Received: 3 May 2019 / Revised: 17 June 2019 / Accepted: 21 June 2019 / Published: 23 June 2019
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Abstract

Background and objectives: Gastric cancer (GC) is one of the deadliest malignancies, with the underlying pathophysiological mechanisms still not completely understood. In this study, we aimed to investigate the signal transducer and activator of transcription 3 (STAT3) moleculeconnection with the pathological features of GCs, and the expression of cell adhesive molecules (E-cadherin and β-catenin) and angiogenesis-related factors (vascular endothelial growth factor (VEGF), HIF1α, and CD31)). Materials and Methods: This study comprised 136 cases of GCs with data related to the patients’ demographic characteristics (age, gender) and pathological features (tumor location, gross type, Laurens’ type of GC, histological differentiation, invasion depth, lymphovascular invasion and the presence of metastases) which were correlated with STAT3 expression. Additionally, STAT3 expression and the expression of adhesive molecules and angiogenesis-related factors were studied by immunohistochemical methods. Results: The expression of STAT3 was found to be significantly associated with the occurrence of poorly differentiated GCs in the lower portion of the stomach and with the presence of distant metastases. Interestingly, none of the investigated parameters related to cell adhesion or to angiogenesis were found to be related to the expression of STAT3. Conclusions: The lack of significant differences between the studied STAT3 expression and some of the molecules associated with different cancer features might be due to the characteristics of the studied population sample associated with the origin, heterogeneity, and cancer pathophysiological background. Nonetheless, the results of our study suggest that STAT3 could be a useful marker for the presence of distant GC metastases, which further indicates that STAT3 action might involve some other signaling molecules/pathways that warrant further elucidation. View Full-Text
Keywords: gastric cancer; STAT3; cancer aggressiveness; angiogenesis; cell adhesion gastric cancer; STAT3; cancer aggressiveness; angiogenesis; cell adhesion
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Krstić, M.; Stojanović, N.M.; Stojnev, S.; Radenković, G.; Čukuranović Kokoris, J.; Mladenović, B.; Janković Veličković, L. Interplay between STAT3, Cell Adhesion Molecules and Angiogenesis-Related Parameters in Gastric Carcinoma. Does STAT3 Really Have a Prognostic Value? Medicina 2019, 55, 300.

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